Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes
Journal Title: Медичні перспективи - Year 2017, Vol 22, Issue 2
Abstract
The article presents the results of study of cadmium accumulation in the internal organs of Wistar rats after prolonged intraperitoneal administration of cadmium chloride and cadmium sulphide nanoparticles of 4-6 nm and 9-11 nm in size in a dose of 0.08 mg /kg/day calculated as cadmium. Toxic effects were evaluated after 30 injections (1.5 months), 60 injections (3 months), and 1.5 months after the exposure has been ceased. The results of the study showed that the most intensive accumulation of cadmium was observed in the kidneys and liver of experimental animals, which is due to the peculiarities of the toxicokinetics and the route of administration of cadmium compounds. In the kidneys, spleen and thymus of animals exposed to cadmium sulphide nanoparticles, a greater concentration of cadmium than in the organs of animals exposed to cadmium chloride was found. Cadmium accumulated more intensively in the spleen after exposure to larger nanoparticles, than in the kidneys and thymus. In the liver, heart, aorta and brain significant accumulation was observed after cadmium chloride exposure.
Authors and Affiliations
O. L. Apykhtina, K. P. Kozlov
Keywords
Related Articles
- EP ID EP229573
- DOI 10.26641/2307-0404.2017.2.109707
- Views 99
- Downloads 0
Inhibitory mechanism of influence of thyroid hormones on cognitive function of the brain
In experiments on young rats there were studied changes in the fatty acid spectrum of fraction of free fatty acids (FFA) of neocortex and hippocampus in conditions of thyroid dysfunction. Elevated levels of thyroid ho...
Місце біомаркерів у діагностиці, стратифікації ризику та прогнозуванні серцевої недостатності
Место биомаркеров в диагностике, стратификации риска и прогнозировании сердечной недостаточности. Ханюков А.А., Сапожниченко Л.В. Сердечная недостаточность занимает одно из ведущих мест в структуре причин смертности взр...
Water supply of Zaporizhzhya Priazovye: nascent, stages of development, problems of nowadays and hygienic substantiation of ways of their solutions
At the modern stage of development humanity is on the verge of the pandemic of non-communicable diseases. It is not an exception for the population of the Ukraine, among which more than 2/3 of the total morbidity inciden...
Influence of insulin resistance on renal function in patients with abdominal obesity
The purpose of the study - to assess the role of insulin resistance in the development of initial manifestations of renal disease in patients with abdominal obesity. Materials and methods – 61 patients (I group) young wi...
Tissue features of lipid peroxidation in rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives
The research of LPO state of white rats in conditions of the long-term influence of oxyethylized nonylphenols and their derivatives was carried out. It was established, that oxyethylized nonylphenols on day 45 of influen...