Dynamics of prooxidant and antioxidant homeostasis rates in patients with rosacea in the process of integrated treatment
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 1
Abstract
Objective — to determine the dynamics of prooxidant and antioxidant homeostasis rates in patients with rosacea by using an antioxidant drug in their multimodality treatment. Materials and methods. The study involved 64 patients with rosacea (49 women and 15 men), aged 28 to 63; 23 of them were diagnosed with erythematoustelangiectastic and 41 with papulopustular stage (form) of rosacea. In the course of treatment the patients with rosacea were divided into 2 groups: group І (comparative reference group) consisted of 32 patients who received a standard treatment of dermatosis, group ІІ (main group) included 32 patients, who were administered an antioxidant ethylmethylhydroxypyridine succinate (mexidol) in addition to the standard therapy. The status of the blood prooxidant system was assessed by the content of malonic aldehyde (MA) in plasma and in red blood cells and the fractions of protein oxidative modification of the neutral (POM Е370) and the main (POM Е430) nature — in the blood serum; while the status of endogenous intoxication was evaluated by the content of the midmolecular peptides — medium mass molecules (MMM) in the blood serum; the status of the antioxidant blood system — by the reduced glutathione (RG) rate in the blood hemolysate and by the content of ceruloplasmin in the blood serum according to available methods. Results and discussion. Before the treatment the patients with rosacea in both comparative and main groups had a reliable (р < 0.05) compared to the values in the individuals of the control group, increase in the content of MA in plasma (by 53.9 and 51.9 % respectively) and in the red blood cells (by 24.3 and 23.5 %), in the blood serum — POM Е370 (76.7 and 70.9 %), POM Е430 (77.9 and 83.0 %), in the serum — МMМ Е254 (by 46.5 and 42.1 %) and МMМ Е280 (68.6 and 72.2 %), as well as an increase in CА (78.2 and 72.7 %) and a decrease in the content of RG in the blood red cells (by 21.2 and 20.6 %). The patients of the I group had a reliable decrease in the blood serum POM Е370 (9.4 %, р = 0.012) and CА (15.3 %, р = 0.005) only, while the patients of the main group, who were additionally administered the antioxidant drug, had a reliable (р < 0.05) decrease in MA in their plasma (by 16.2 %) and in the red blood cells (13.1 %), in the blood serum — POM Е370 (25.7 %), POM Е430 (24.9 %), МMМ Е254 (23.5 %), МMM Е280 (18.7 %) and CА (25.1 %, р = 0.005), as well as an increase in the content of RG in the red blood cells (10.7 %, р = 0.011). The patients of the main group also had better clinical results after completing the complex treatment. Conclusion. Administrating the antioxidant ethylmethylhydroxypyridine succinate (mexidol) to the patients with rosacea additionally to a standard therapy contributes to the normalization or trends towards to the normalization of prooxidant and antioxidant homeostasis rates and improves clinical outcomes of treatment of such patients.
Authors and Affiliations
M. V. Storozhuk
Keywords
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