Early identification of heart failure in patients with thalassemia major by NT-pro-BNP examination. Correlation with echocardiographic parameters of morphology and function
Journal Title: International Journal of Medical and Health Research - Year 2017, Vol 3, Issue 12
Abstract
Aims: To identify early heart failure in patients with thalassemia major by examining NT-pro-BNP and to correlate echocardiographic parameters. Materials and methods: We evaluated 37 consecutive patients with homozygous β-thalassemia and 50 age-matched healthy controls by NT-pro-BNP levels and echocardiography. Results: NT-proBNP levels were significantly higher in TM cohort compared to healthy controls 169.3±166.3 versus 33±19.5 pg/ml. (р<0.001). There were 11 (29.7%) patients with elevated NT-pro-BNP. Ultrasound and MRI LAVi (ml/m²) were significantly enlarged with borderline depression of left atrial emptying fraction. TM NT-proBNP+) had significantly larger left atrial volume index LAVi (p=0.025) compared to TM NT-proBNP-, but all other indices were no different. There was a moderate yet significant correlation between NT-pro-BNP and LAVi – r=0.44, p=0.009 and between LVMMi and LAVi- r = 0.480, p= 0.004. Conclusions: The only significant difference between the two TM groups - NT-proBNP positive and NT-proBNP negative was left atrial volume index LAVi
Authors and Affiliations
Branimir Kanazirev, Maria Dimova, Valeria Kaleva, Svetlana Gercheva, Kristina Petrova, Vesela Zlateva
Keywords
Related Articles
- EP ID EP587375
- DOI -
- Views 149
- Downloads 0
Bronchiolitis and respiratory pneumonia virus: A review
Bronchiolitis is characterized by bronchial epithelium necrosis, caused by the virus, increased mucus secretion and cellular infiltration and edema under the mucosa. These changes result in the formation of bronchial obs...
Ankle Dislocation without fracture in a young Athlete: A rare case and review of literature
We report a case report of a 24-year-old male who sustained an ankle dislocation injury without any associated fractures to the foot, ankle, or leg while playing basketball. After an extensive review of the literature, i...
Evaluation of novel mouthwash on dental remineralization
The microorganisms are responsible for the generation of the acids which lead to the demineralization and weakening of the enamel. Hence based on these findings the present study was planned to demonstrate the effect of...
A randomized clinical study to evaluate effect of dexamethasone with levobupivacaine in sciatic nerve block for post-operative pain relief
Background: Pain is an unavoidable experience in postoperative period. If untreated or undertreated may result in increased morbidity as well as the cost because of impairment of quality of life. Aims and Objectives: To...
Assessment on risk factors and incidence of renal stones
Renal stone is a common and a major cause of morbidity worldwide including India. In general, urinary stones may contain various combinations of chemicals that become concentrated enough in the urine to form crystals. A...