Early Prognostic Values of Cardiac Biomarkers in ST elevation Myocardial İnfarction patients that underwent Percutaneous Coronary Intervention
Journal Title: Anatolian Journal of Emergency Medicine - Year 2018, Vol 1, Issue 2
Abstract
Objective To assess the early prognostic values of admission cardiac biomarkers; CKMB (Creatine kinase MB isoenzyme), hs-Troponin T (high-sensitivite troponin T) and BNP (Brain natriüretic peptide) in patients with STEMI (ST elevation myocardial infarction) by determining the association of these markers with mortality, Gensini scores and LAD (Left Anterior Descending artery) involvement prospectively. Materials and Methods The current study was performed through the six month period on seventy STEMI patients admitted to ED who underwent to percutaneous coronary intervention (PCI). Admission first cardiac biomarker values measured within 6 hours, patient demographics and clinical characteristics (age, gender, PCI results, LAD involvement) and Gensini scores calculated in regards to PCI results were recorded. Associations of each cardiac biomarker (CKMB, hs-Troponin T, BNP) with the presence of mortality and LAD involvement were calculated. Correlation between biomarker levels and gensini scores were sought with Spearman correlation coefficients test. Results BNP (p=0.005) and hs-Troponin T (p=0.002) were associated with increased mortality. There was no association between mortality and the first admission value of cardiac biomarkers (BNP, CK-MB, hs-troponin T) with Gensini score (p>0.05). Higher BNP values indicated higher LAD (+) lesion probability (p<0.05) while no association between LAD (+) lesion and the other biomarkers (CKMB, hs-Troponin T) (p>0.05). Conclusions Acute STEMI with high BNP and hs-Troponin T levels predict increased mortality and needs more serious treatment and close follow-up. Additionally higher BNP levels suggest a potential LAD (+) lesion which is closely related with mortality. Admission BNP and hs-Troponin T values indicate early prognostic outcome in STEMI patients, however they don’t point out the severity of the lesions.
Authors and Affiliations
Can Aktaş, Gökçe Akgül Karadana, Elif Değirmenci, Yoldaş Demirtaş, Şevki Hakan Eren
Keywords
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