Effect of a medicinal agent, possessing antioxidant and antihypoxant properties, on the state of oxygen homeostasis and lipid peroxidation under experimental pneumoconiosis in albino rats
Journal Title: Progress in Health Sciences - Year 2018, Vol 8, Issue 2
Abstract
Introduction: Pneumoconioses (Pc) are interstitial pulmonary diseases of professional genesis, caused by long-term inhalation of high dust concentrations. Pcafflict 26.6-53% of the workers, exposed to dust contamination. The major feature of Pc course is irrevocability and incurability. Purpose: The research of the effect of ethylmethyl hydroxypyridine succinate, possessing antioxidant and antihypoxant characteristics, on the oxygen metabolism, acid-alkaline state, and lipid peroxidation at the background of experimental pneumoconiosis in albino rats. Material and methods: Pneumoconiosis was simulated on 72 albino rats through endotracheal injection of black coal suspension, on our own modification of O. Yu. Nykolenko methodology. Results: Manifestations of experimental pneumo-coniosis depended on the period of dust inhalation. Development of experimental pneumoconiosis was found to result in the decreased partial oxygen pressure in the arterial blood, compensated hyperventilation-induced respiratory alkalosis, and marked increase in lipid peroxidation activity that could be seen in the blood content of malon-dialdehyde, as well as of conjugated dienes and trienes. Conclusions: Application of ethylmethylhydroxy pyridine succinate in experimental pneumoconiosis has been found to improve oxygen metabolism, acid-alkaline state, and lipid peroxidation that is revealed in normalization of the partial oxygen pressure in the arterial blood, oxygen saturation of haemoglobin, index of bases’ deficiency BE (Ваse-Ехсеss), and in 1.6-2.0 decrease in the content of malondialdehyde, as well as of conjugated dienes and trienes.<br/><br/>
Authors and Affiliations
A. Olyinyk, A Ślifirczyk, M. Nikoniuk, D> Domańska
Keywords
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- DOI 10.5604/01.3001.0012.8336
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