EFFECT OF AFLATOXIN M1, "A HYDROXYLATED METABOLITE OF B1" ON SPERM CELL QUALITY OF ADULT MALE WISTAR RATS.
Journal Title: International Journal of Current Research in Physiology and Pharmacology - Year 2019, Vol 3, Issue 2
Abstract
The effect of aflatoxin on reproductive health takes a systematic approach as it indicates that a significant number of people living in the third world regions are exposed to these toxins due to the poor storage of grains. To expose the effects of aflatoxin M1 a hydroxylated metabolite of aflatoxin M1 Twenty four Adult male Wister rats were acclimatized and broken down into four groups, Test Group one (Two weeks exposure), Group Two ( four weeks exposure), Group Three ( Six weeks exposure) and Group Four ( Control Group). The Test Group 1, 2 and 3 were orally administered 7.2g/kg (LD50) of Aflatoxin M1 for the desired weeks of exposure and the sperm cell quality was assessed to determine the effect of Aflatoxin M1 on sperm cell quality in Adult male wister rat. The predetermined level of sperm cell quality is its ability to be motile as the motility of the sperm cell determines its viability. Group three had the highest presence of sluggishly immotile cells with very low progressive motility, followed by group, two and one, 37.5+ 9.97, 55.00+9.91, and 71.67+3.07 as against the control groups 85.8+2.17 with the highest significance at the group three which showed an extended exposure of aflatoxin m1 (p=0.05). This study links infertility and aflatoxin consumption, as the higher the doses the more spermatotoxicity is built which invariably could lead to sterility and azoospermia.
Authors and Affiliations
Ibeh Nnanna, Taidi Ekrakene, Okungbowa MO, Otabor Florence, Omorodion Terry
Keywords
Related Articles
- EP ID EP564691
- DOI 10.31878/ijcrpp.2019.32.2
- Views 105
- Downloads 0
OBESITY AS RISK FACTOR IN TYPE-2 DIABETES MELLITUS IN MIDDLE AGED WOMEN
Background: Type 2 diabetes is a common chronic disease resulting from a complex inheritance-environment interaction along with other risk factors such as obesity and sedentary lifestyle. Type 2 diabetes and its complica...
EFFECT OF CIGARETTE SMOKING ON PEAK EXPIRATORY FLOW RATE: A SHORT REVIEW
Tobacco smoking in India has been increasing alarmingly. Smoking is a known risk factor for chronic obstructive pulmonary disease (COPD), cardiovascular diseases and certain cancers, especially, the lung cancer. Carbon m...
Cutaneous Complications in Macrolide Prescribing in Pediatrics
Cutaneous adverse reactions are very common adverse effect of post antibiotic therapy. Cutaneous adverse reactions include skin lesions in the form of rashes urticaria, maculopapular rashes, eythema multiforme, stevens-j...
Effects of alpha, beta momorcharin fruit extract with the combination of paclitaxel in the treatment of glioma cancer in-vivo.
The vegetable Momordica charantia L., (family: Cucurbitaceae) is a scientific name of the plant and its fruit. It is also known by other names, for instance in the USA it is known as Bitter gourd or balsam pear while its...
AN EVALUATION OF FIXED DOSE COMBINATIONS (FDCs) USED FOR TREATMENT OF DIABETES IN INDIAN MARKET
Objective: To analyse the rationality of various FDCs used in the treatment Diabetes Mellitus and to find out the irrational FDCs existing in Indian market. Material and Methods: Study Design: Analytical study. Data on F...