Effect of Atenolol and Enalapril on Oxidative Stress in Pre and Postmenopausal Women with Essential Hypertension
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Background: There is an increased risk of morbidity and mortality in pre and postmenopausal hypertensive patients due to metabolic abnormality which leads to formation of free radicals. Hence; we estimated the oxidative stress in pre and postmenopausal essential hypertensive patients before and after the treatment with atenolol and enalapril. Materials and Methods: 348 outpatient essential hypertensive women were selected for the study. The subjects selected were between the age group 30 to 70 years. All the subjects were divided into two groups, premenopausal hypertensive women and postmenopausal hypertensive women. The subjects in the premenopausal hypertensive women group had age 30-50 years. The subjects in postmenopausal hypertensive group had age 50 to 70 years. Equal numbers of patients from each group were selected for antihypertensive drugs, atenolol and enalapril. Results: An increase in the level of superoxide dismutase, glutathione peroxidase against parallel decrease in the levels of malondialdehyde was observed. Pre and postmenopausal hypertyensive women treated with enalapril had highly significant concentration of above given oxidative parameters as compoared to those who were treated with atenolol. Conclusion: Increased production of nitric oxide from the lungs induced by ACE-inhibitor, enalapril may be mediated by inhibition of angiotensin II production.
Authors and Affiliations
Raj Kumar Das, Vaishali R. Das, Juilee D. Sawalakhe, Shailaja R. Raghatate
Keywords
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- EP ID EP542349
- DOI 10.21276/ijmrp.2017.3.1.034
- Views 73
- Downloads 0
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