EFFECT OF CENTRALLY ADMINISTERED NITRIC OXIDE MODULATORS IN CARRAGEENIN-INDUCED NOCICEPTION IN RATS
Journal Title: International Journal of Agricultural Science and Research (IJASR) - Year 2017, Vol 7, Issue 1
Abstract
Possible modulation of carrageenin induced nociception by centrally (ICV) administered nitric oxide (NO) modulators was investigated. In rat, inhibitors of nitric oxide synthase inhibitors (NOS), precursor of nitric oxide (NO) with SIN-1, L-Name and haemoglobin (Hb) was explored. Nitric acid donors and scavengers are also evaluated. The pain threshold capacity is increased significantly while administration of NOS inhibitors and NO scavenger Hb whereas as hyperalgesic effect was resulted while administration of nitric oxide donors SIN-I, SNP and L-arginine. The nociceptive behavior of rat was failed to alter by D-arginine while co-administration of SIN-I with L-Name and haemoglobin found to increase the threshold level. These results showed alteration of nociceptive transmission induced by Carrageenin in rats after administration of nitric oxide modulators.
Authors and Affiliations
JADAV SARMA, SURENDRA KUMAR TANDON, SANJIB KHARGHARIA, HIMANGSHU BARUAH
Keywords
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