Effect of chloroquine on phagolysosomal fusion in cultured guinea pig alveolar macrophages: Implications in drug delivery
Journal Title: The AAPS Journal - Year 2000, Vol 2, Issue 4
Abstract
Authors and Affiliations
Meenakshi Bhat, Anthony J. Hickey
Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid: Inhibition of Active Renal Reabsorption as a Potential Therapeutic Strategy
γ-Hydroxybutyric acid (GHB), a drug of abuse, exhibits saturable renal clearance and capacity-limited metabolism. The objectives of this study were to construct a mechanistic toxicokinetic (TK) model describing s...
How Promiscuous Are Pharmaceutically Relevant Compounds? A Data-Driven Assessment
The online version of this article (doi:10.1208/s12248-012-9421-y) contains supplementary material, which is available to authorized users.
A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics
A mathematical pharmacokinetic/anti-drug-antibody (PK/ADA) model was constructed for quantitatively assessing immunogenicity for therapeutic proteins. The model is inspired by traditional pharmacokinetic/pharmacodynamic...
MicroPET investigation of chronic long-term neurotoxicity from heavy ion irradiation
Positron emission tomography (PET) permits imaging of the regional biodistribution and pharmacokinetics of compounds labeled with short-lived positron-emitting isotopes. It has enabled evaluation of neurochemical systems...
Common Reasons for “For-Cause” Inspections in Bioequivalence Studies Submitted to the Food and Drug Administration
“For-cause” inspections are initiated during the review of bioequivalence (BE) data submitted to Abbreviated New Drug Applications when possible scientific misconduct and study irregularities are discover...