Effect of Chronic Proton Pump Inhibitor Use on Serum Magnesium Levels in Pediatric Patients
Journal Title: Gastro - Open Journal - Year 2015, Vol 1, Issue 4
Abstract
Hypomagnesemia has been reported in adult patients on Proton Pump Inhibitor (PPI) therapy. No studies have described the effect of this class on medications on Magnesium (Mg) levels in children. This was a retrospective cohort study assessing serum Mg levels in patients on PPI therapy followed by a pediatric gastroenterology service at a tertiary center. The study included 31 patients with a mean age of 7.8 years with 74 serum Mg levels. Duration of PPI therapy ranged between few days to more than 8 years. The main indication for PPI therapy was gastroesophageal reflux disease. Only 2 patients, of adult age, had Mg levels below the normal reference limit of 1.6 mg/dL. In one patient, multiple risk factors for hypomagnesemia were noted. For the entire cohort, there was no statistically significant difference in serum Mg levels over time or with chronic use (defined as more than 2 years). This study did not identify any patient less than 18 years of age with hypomagnesemia while on PPI therapy. Prospective larger long-term pediatric studies may still be needed to better assess the incidence of hypomagnesemia in children on PPI therapy.
Authors and Affiliations
Riad Rahhal
Keywords
Related Articles
- EP ID EP555828
- DOI 10.17140/GOJ-1-118
- Views 119
- Downloads 0
Mucinous Tumour in Ileal Pouch Post Restorative Proctocolectomy and Ileal Pouch Anal Anastomosis for Familial Adenomatous Polyposis
We present a fifty-six years old female having surveillance gastroscopy and colonoscopy ten years after a restorative proctocolectomy and Ileal-pouch anal anastomosis (IPAA). This was performed for Familial Adenomatous P...
Gastric Diverticulum Misdiagnosed as a Left Adrenal Lesion
We report a case of gastric diverticulum misdiagnosed as a left adrenal lesion on both ultrasound and CT imaging and later identified on a follow-up CT. A 56 year-old man with a history of gastroesophageal reflux disease...
Massive Gastric Variceal Bleeding in a Patient with Chronic Pancreatitis
Left-sided portal hypertension (LSPH) is a rare form of portal hypertension that usually occurs as a result of isolated obstruction and thrombosis of the splenic vein. We present a case of a 45-year-old male patient with...
Therapeutic and Chemopreventive Effects of Ursodeoxycholic Acid (UDCA): Potential Role in Patients with Barrett’s Esophagus
Ursodeoxycholic Acid (UDCA) is widely used for the treatment of cholestatic liver diseases. Major mechanisms of this action are protection of cholangiocytes against cytotoxicity of hydrophobic bile acids, stimulation of...
Robot-Assisted Minimally Invasive McKeown Esophagectomy with a Four-Arm Platform: Technique and Early Experience
Objectives: We report an early, single-institution experience of Robot-Assisted Minimally Invasive McKeown Esophagectomy (RAMIME) using a four-arm platform. The technique details, rationale, complications, and pitfalls d...