Effect of Combined Aerobic and Anaerobic Training on Hemodynamic Response, Serum Oxidative Stress Markers and Platelet ATP Synthase Activities in Patients with Coronary Heart Disease: A Pilot Study
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 8, Issue 11
Abstract
Background: The overall aim of this work was to study the impact of combined aerobic and anaerobic training in relation to hemodynamic response (heart rate, systolic blood pressure, and double product), serum oxidative stress markers (lipoperoxides, nitrites-nitrates) and platelet ATP synthase activities in patients with coronary heart disease. Materials and Methods: Ten subjects, 9 male and 1 female, (mean age 57.7±7.2 years) with coronary heart disease participated in this study. Patients performed combined aerobic and anaerobic exercise for 24 sessions (three times a week). Results: The results suggest myocardium adaptations, manifested in the reduction of heart rate with increased workloads and increased double product [(heart rate) x (systolic blood pressure)] according to the intensity, frequency and duration of training. The ATP synthesis rate was significantly increased at session 3 (post-exercise) compared to session 1 (pre exercise). Furthermore, rate of ATP hydrolysis was significantly decreased at session 24 (post-exercise 3) compared to session 1 (post-exercise 1). Serum lipid peroxidation products and nitric oxide catabolites were significantly diminished at session 24 (pre-exercise). Conclusion: In some patients hemodynamic responses showed improvements in response to exercise. The exercise sessions induced lower levels of lipid peroxidation products, nitric oxide catabolites and ATPase activity. Conversely, ATP synthase activity showed higher values at the end of the experiment. These results confirm the beneficial effect of combined aerobic and anaerobic exercise.
Authors and Affiliations
José A. Villarruel-Sahagún, Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Evelia Martínez-Cano, Salvador G. Gómez, Efraín Gaxiola-López, Gustavo Marín-Pineda, Pedro G. Fajardo, Erika D. González-Renovato, Sergio A. Sánchez-Luna, Moisés A. Alatorre-Jiménez, Fernando Cortés-Enríquez, Juan P. Sánchez-Luna
Keywords
Related Articles
- EP ID EP347735
- DOI 10.9734/BJMMR/2015/15421
- Views 61
- Downloads 0
Fungal Infections in Aseer Central Hospital: A Retrospective Laboratory-based Study of 340 Cases during the Years 2011 to 2015
Objectives: The incidence of fungal infections is increasing due to increasing episodes of risk factors such as immune competence; broader used of antibiotics and longer hospital stays. This study aimed to analyze fungal...
Dyslipidemia in HIV Infected Children and Adolescents on Highly Active Antiretroviral Therapy in Abuja, Nigeria
Background: Compelling evidence exists on the usefulness of highly active antiretroviral therapy in the improvement of life of people living with HIV. There is however growing concern from its prolong exposure in childre...
Lymphangioma of Nasopharynx in an Adult: A Rare Case
Lymphangiomas are rare benign congenital malformations of the lymphatics, most often encountered during childhood. Generally they are found in the head and neck region, isolated involvement of the nasopharynx is very rar...
Falls in Elderly with Plantar Changes
Aims: The purpose of this study was to evaluate the prevalence of falls among older people with plantar changes in order to preserve their autonomy and independence. Study Design: A cross-sectional, descriptive, analytic...
Improving Crowding in Dyslexic Children by Visual Training: Conflicting Results from a Single-masked Crossover Pilot Study
Aims: To evaluate the effectiveness of visual training aimed at reducing crowding in dyslexic children. Study Design: Single-masked crossover pilot study. Place and Duration of Study: University of Turin and the Graden...