Effect of cysteamine on bile secretion in the rat.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 3
Abstract
The effect of cysteamine, a specific somatostatin depletor, on biliarysecretion was studied in urethane-anesthetized rats. Different groups of rats received ip cysteamineat 25, 100 or 340 mg/kg just before bile collection commenced. Other groups of rats were pretreated withcysteamine (340 mg/kg ip) at 4 or 24 h prior to bile duct cannulation and bile collection. Bile secretionswere collected at 30-min intervals for 4 h after bile duct cannulation. Total proteins, cholesterol,total lipids, glucose and several hepatic enzymes were assessed in bile. Results indicated that basalbile secretion was only slightly reduced and tended to decrease after drug administration ( 13% decreaseafter 340 mg/kg). Cysteamine induced dose-dependent decrease in protein secretion, and the maximum effectwas reached at a dose of 340 mg/kg. The effect of cysteamine on protein secretion was prolonged, sinceit was still observed 24 h after the treatment with cysteamine. Cholesterol and lipid secretion was inhibitedby 52.5 and 42.5%, respectively, by the drug, with the latter effect being evident 24 h after drug administration.In addition, the drug inhibited biliary glucose and aspartate aminotransferase concentrations, but increasedthat of alkaline phosphatase. The results suggest that acute administration of cysteamine inhibits protein,cholesterol and lipid secretion into bile.
Authors and Affiliations
Omar Abdel Salam, Ayman Baiuomy, Siham El-Shenawy
Keywords
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