Effect of Dexmedetomine on Haemodynamics and Isoflorane Requirement during Laparoscopic Cholecystectomy

Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 1

Abstract

Minimal access surgery like laparoscopic cholecystectomy has several advantages like less pain, early mobilisation, shorten stay in hospital and better cosmetic results. Due to the haemodynamic response to pneumoperitoneum, laparoscopic procedures are not free from risk. Uses of dexmedetomidine during general anaesthesia attenuate the haemodynamic response of pneumoperitoneum. In this study we evaluate the effect of dexmedetomidine on haemodynamic and the isoflorane requirement. A prospective randomised and double-blind study was conducted in 50 patients by dividing them in two groups. Group C as control (normal saline infusion) and Group D (dexmedetomine infusion) as test. Standard anaesthesia procedure is followed. During anaesthesia bispectral index (BIS) monitoring is done and it was maintained in the range of 40–60 with the titration in the dose of inhalational anaesthetic (isoflorane). Result shows that there is significant haemodynamic stability (P < 0.05) and 70% reduction in the requirement of isoflorane (P < 0.05) in Group D as compared to Group C. BIS was maintained in the range of 40–60. It is concluded that the use of Dexmedetomine results in better haemodynamic and requirement of inhalational anaesthetic can be reduced.

Authors and Affiliations

Rajeev Kumar

Keywords

Related Articles

Herpes Zoster in Cholelithiasis Patient – Surgeons’ Dilemma

Herpes zoster often causes diagnostic difficulties. We report two cases of herpes zoster presented in our surgery outpatient department as pain abdomen. One patient was in acute eruptive phase and another was in pre-erup...

Optimum Initiating Pressure of Nasal CPAP in Newborns with Moderate Respiratory Distress: A Randomised Controlled Trial

Objective To decide the optimum initiating pressure of nasal CPAP in newborns with respiratory distress. Methods The study was done in neonatal intensive care unit (NICU) between November 2009 and November 2011 as a pros...

Arteriovenous Malformation of the Oral Cavity: A Case Report and Review of Literature

Arteriovenous malformations (AVMs) are developmental vascular anomalies that occur when the embryonic vascular network fails to differentiate. It is composed of abnormal communications between arteries and veins without...

A Promising Dual-functional Neuroprotective Derivative of Memantine

Background Memantine, an open-channel, uncompetitive blocker of NMDA receptors, is a major treatment for moderate-to-severe Alzheimer’s disease. The NMDA receptor activity can also be inhibited allosterically by S-nitros...

Analysis of Prescribing Patterns of Antihypertensive and Antidiabetic Medications in Patients

Background Prescription of irrational drug is now a day’s a common practice globally; it can result in increase on morbidity, mortality and economic burden on society. Aims and Objective To study on drug prescribing patt...

Download PDF file
  • EP ID EP184006
  • DOI -
  • Views 117
  • Downloads 0

How To Cite

Rajeev Kumar (2016). Effect of Dexmedetomine on Haemodynamics and Isoflorane Requirement during Laparoscopic Cholecystectomy. Journal of Pharmaceutical and Biomedical Sciences, 6(1), 6-9. https://europub.co.uk./articles/-A-184006