Effect of Dexmedetomine on Haemodynamics and Isoflorane Requirement during Laparoscopic Cholecystectomy
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 1
Abstract
Minimal access surgery like laparoscopic cholecystectomy has several advantages like less pain, early mobilisation, shorten stay in hospital and better cosmetic results. Due to the haemodynamic response to pneumoperitoneum, laparoscopic procedures are not free from risk. Uses of dexmedetomidine during general anaesthesia attenuate the haemodynamic response of pneumoperitoneum. In this study we evaluate the effect of dexmedetomidine on haemodynamic and the isoflorane requirement. A prospective randomised and double-blind study was conducted in 50 patients by dividing them in two groups. Group C as control (normal saline infusion) and Group D (dexmedetomine infusion) as test. Standard anaesthesia procedure is followed. During anaesthesia bispectral index (BIS) monitoring is done and it was maintained in the range of 40–60 with the titration in the dose of inhalational anaesthetic (isoflorane). Result shows that there is significant haemodynamic stability (P < 0.05) and 70% reduction in the requirement of isoflorane (P < 0.05) in Group D as compared to Group C. BIS was maintained in the range of 40–60. It is concluded that the use of Dexmedetomine results in better haemodynamic and requirement of inhalational anaesthetic can be reduced.
Authors and Affiliations
Rajeev Kumar
Keywords
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