Effect of eradication of Helicobacter pylori in rheumatoid arthritis patients
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
[i]Helicobactor pylori (H. pylori)[/i] is suspected to be one of the factors triggering rheumatoid arthritis. The aim of this study was to evaluate the effect of [i]H. pylori[/i] eradication on inflammatory disease activity in patients with rheumatoid arthritis. The presence of [i]H. pylori[/i] was assessed in 59 patients with rheumatoid arthritis from whom [i]H. pylori [/i]was eradicated. The level of inflammatory disease activity was evaluated before eradication and during a 42-week follow-up period, as well as the inflammatory disease. The activity of [i]H. pylori[/i] in uninfected patients was evaluated with similar time intervals. A significant improvement was seen in the patients’ ESR after [i]H. pylori [/i]eradication, although this was non-significant after adjustment for multiple comparisons. A significantly reduced number of tender joints was observed in patients unaffected by [i]H. pylori[/i], possibly due to altered DMARD-treatment in 17% of the patients. Our results indicate the role of [i]H. pylori [/i]on the inflammatory state of rheumatoid arthritis, but further studies on larger populations are necessary for final conclusions to be drawn.
Authors and Affiliations
Lykke B. Graff, Leif P. Andersen, Anne Gernow, Stig Bondesen, Annie Bremmelgaard, Olaf Bonnevie, Bente Danneskiold-Samsøe, Else M. Bartels
Keywords
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