Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers
Journal Title: The AAPS Journal - Year 2008, Vol 10, Issue 2
Abstract
Ethanol significantly increased the permeability of oxycodone, oxymorphone and atenolol in a concentration-dependent (1–5%) manner. The permeability of hydromorphone and metoprolol were not altered by ethanol. These results suggest that alcohol increases the transport of low permeability drugs through Caco-2 cell monolayers, consistent with results from clinical bioavailability studies. Thus, cell permeability assay can assist in determining the influence of low ethanol concentrations on drug transport through the intestine.
Authors and Affiliations
Donna A. Volpe, Ebenezer B. Asafu-Adjaye, Christopher D. Ellison, Suresh Doddapaneni, Ramana S. Uppoor, Mansoor A. Khan
Keywords
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- EP ID EP681555
- DOI 10.1208/s12248-008-9046-3
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