EFFECT OF EXERCISE TRAINING OF DIFFERENT INTENSITIES ON ANTI-INFLAMMATORY REACTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Journal Title: Biology of Sport - Year 2014, Vol 31, Issue 1
Abstract
The study investigated the effect of high- and low-intensity exercise training on inflammatory reaction of blood and skeletal muscle in streptozotocin (STZ)-induced diabetic male Sprague-Dawley rats (243 ± 7 g, 8 weeks). The rats completed treadmill running in either high-intensity exercise (6 weeks of exercise training, acute bouts of exercise) or low-intensity exercise (6 weeks of exercise training). Non-running, sedentary rats served as controls. To induce diabetes mellitus, rats received a peritoneal injection of STZ (50 mg · kg[sup]-1[/sup]). Rats were sacrificed immediately after an acute bout of exercise and 6 weeks of exercise training. Inflammatory factors were analyzed by ELISA and by immune blotting from the soleus and extensor digitorum longus muscles. In the serum, inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-4) and reactive oxygen species (ROS) (nitric oxide and malondialdehyde) increased in diabetic rats. However, all exercise training groups displayed reduced inflammatory cytokines and reactive oxygen species. In skeletal muscles, low-intensity exercise training, but not high intensity exercise, reduced the levels of COX-2, iNOS, and MMP-2, which were otherwise markedly elevated in the presence of STZ. Moreover, the levels of GLUT-4 and MyoD were effectively increased by different exercise intensity and exercise duration. Low-intensity exercise training appeared most effective to reduce diabetes-related inflammation. However, high-intensity training also reduced inflammatory factors in tissue-specific muscles. The data implicate regular exercise in protecting against chronic inflammatory diseases, such as diabetes.
Authors and Affiliations
Jeong-Seok Kim, Young-Hee Lee, Jae-Cheol Kim, Young-Ho Ko Ko, Chung-Su Yoon, Ho-Keun Yi
Keywords
Related Articles
- EP ID EP59191
- DOI -
- Views 98
- Downloads 0
Family studies of somatic and functional characteristics in the polish rural population
In the present investigation we were trying to determine the genetic and environmental conditioning of the chosen somatic and functional traits in Polish rural population during ontogenesis. In order to find out interact...
Effects of two months training on blood lactate levels in adolescent swimmers
The aim of this study is to examine the effects of two months swimming training on aerobic and anaerobic capacities with blood lactate. A total of 17 adolescent male swimmers (15.17±0.81 years) were included in the study...
KINEMATIC VARIABLES AND BLOOD ACID-BASE STATUS IN THE ANALYSIS OF COLLEGIATE SWIMMERS’ ANAEROBIC CAPACITY
Short duration repeated maximal efforts are often used in swimming training to improve lactate tolerance, which gives swimmers the ability to maintain a high work rate for a longer period of time. The aim of the study wa...
The analysis of gait in people with Down syndrome – comparison with the norm in healthy people
The analysis of gait in people with Down syndrome, mentally retarded to a moderate and considerable degree, and a comparison of the results achieved to the gait norm elaborated for healthy people were the main interests...
EFFECT OF LOW-IMPACT AEROBIC DANCE EXERCISE ON PSYCHOLOGICAL HEALTH (STRESS) AMONG SEDENTARY WOMEN IN MALAYSIA
The present study investigated the effect of twelve weeks of low-impact aerobic dance exercise intervention (“aero-mass” dance exercise) on psychological health (stress) among sedentary working women, specifically in Mal...