EFFECT OF FLAXSEEDS ON ISOPROTERENOL INDUCED CARDIOTOXICITY IN RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 12
Abstract
The present study was performed to explore the potential effects of flaxseed against isoproterenol induced cardiotoxicity in rats. Forty rats classified into control negative group and isoproterenol induced cardiac toxicity (85 mg/kg body weight) four rat groups that reclassified into untreated control positive and flaxseed powder, oil and extract treated rat groups. The study was assigned for 60 day. Administration of flaxseed either in form of powder, oil and extract improve of nutritional indicator (weight gain, food efficiency ratio and protein efficiency ratio) reducing hyperlipidemia (lower serum total cholesterol, LDLc, VLDLc and elevate HDLc), decline in atherogeneses (total cholesterol/ HDLc) normalize values of liver parameters (cholesterol, T. lipids, TG, ALT, AST, ALP and LDH) and antioxidant markers (SOD and catalase along with significant lower in the level of malondialdehyde, cardiac XO, LDH and NO). It can be concluded that the administration flaxseed powder, oil or extract can lower the side effects of isoproterenol induced cardiotoxicity in rats and reducing the risk factors for cardiovascular disease such as hyperlipidemia, leakage of cardiac markers and nutritional indicators.
Authors and Affiliations
Raghad Fayez Alfayez
Keywords
Related Articles
- EP ID EP619231
- DOI -
- Views 155
- Downloads 0
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF KETOPROFEN USING NATURAL GUMS
Sustained release tablets of Ketoprofen is a non steroidal anti-inflammatory drug. Designing a sustained release formulation for the drug ketoprofen may prolong therapeutic concentration of drug in the blood and decrease...
NEONATAL INTENSIVE CARE UNIT & INDICATIONS FOR ADMISSION WITH THEIR RELATION TO GENDER & MODE OF DELIVERY
A study done in Jalawla general hospital in Neonatal Intensive Care Unit which consist of three incubators, where 90 patients in five months included in the study, Gestational age of these patients where between(26_41)we...
SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: A REVIEW
Sustained release drug delivery system can be a major advance toward solving the problem concerning drugs have a short half-life are eliminated quickly from blood circulation require frequent dosing. To avoid this proble...
MYELOMENINGOCELE A COMPARISON THE POST OPERATIVE COMPLICATIONS B/W INFANTS WITH PARAPLEGIA AND THESE WITH VARIABLE DEGREE OF LOWER LIMBSWEAKNESS ASTUDY OF 100 CASES 2013
BACKGROUND: Myelomeningocele is a complex malformation of spinal cord, nerves roots, meninges, vertebral body and skin .this neural tube defect is common congenital anomaly and is typically referred to as spina bifida. T...
HPLC AND HPTLC SIMULTANEOUS DETERMINATION METHODS OF TRICLABENDAZOLE AND MOXIDECTIN IN COMBINED DOSAGE FORMS
This manuscript describes two simple validated chromatographic methods for simultaneous determination of Triclabendazole (TCL) and Moxidectin (MOX) in combined dosage forms with no prior separation or interference from e...