EFFECT OF GLYCOWITHANOLIDES ON SIALIC ACID CONTENT IN SALIVARY GLANDS OF D-GALACTOSE INDUCED AGING MICE
Journal Title: International Journal of Pharmaceutical Applications - Year 2010, Vol 1, Issue 1
Abstract
The study was undertaken to find out effect of glycowithanolides (WSG) extracted from Withania somnifera leaves on sialic acid content in submandibular and sublingual salivary glands of D-galactose induced aging mice. The adult male mice (Mus musculus) were grouped into protective and curative group. Each group further divided into four batches 1) Control batch of protective and curative group received 0.5 ml 0.9% saline per day for 20 days and 40 days respectively. Mice from 2nd, 3rd and 4th batches of protective group received D-galactose, D-galactose+ centrophenoxine and D-galactose + WSG for 20 days respectively. Mice from 2nd, 3rd and 4th batches of curative group received D-galactose for 20 days followed by saline, centrophenoxine and WSG alone for further 20 days respectively. In D-galactose stressed mice sialic acid content was increased significantly in both the submandibular and sublingual salivary glands compared to control. In centrophenoxine and WSG treatment receiving mice there was significant reduction in sialic acid content as compared stressed mice. During aging stress, induced by D-galactose alteration in sialic acid of salivary glands took place. These alterations were prevented by centrophenoxine and WSG.
Authors and Affiliations
R. N. MOTE , M. M. PILLAI , B. K. PAWAR
Keywords
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