EFFECT OF GONADAL HORMONES ON HYPOPHAGIC PROPERTY OF OPIOID ANTAGONIST NALOXONE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 1
Abstract
Background: Studies have shown that hormonal fluctuations that occur over the estrous cycle in rats affect food intake. It is possible that estrogen affects food intake via Opioid system and other brain areas which are involved in regulation of food intake. Therefore it may affect the sensitivity of female rats to hypophagic effect of Opioid antagonist Naloxone. Testosterone in male rats also changes food intake. However, little is known about hoe these Gonadal hormones interact with Opioid receptors to modulate food intake. Objective: The aim of the study was to find out how Gonadal hormones affect hypophagic property of Naloxone. Methods: Basal food intake of 40 healthy adult females and 20 healthy adult male rats was recorded. Then they were injected intraperitoneally with Naloxone after fasting for 24 hrs. In female rats food intake was measured during different phases of the estrous cycle. All the rats were then subjected to gonadectomy. The food intake was measured after gonadectomy. The effect of Naloxone was also measured in deprivation paradigm after gonadectomy. Results: Female rats showed decreased food intake during proestrous and estrous phases. In female rats there was no hypophagia after Naloxone injection during these phases. Male rats showed hypophagia on Naloxone injection. Male rats showed increased food intake after gonadectomy. In female rats the increase in food intake was not significant when gonadectomy was done during metestrous and diestrous. However, Naloxone could induce hypophagia in all female rats after gonadectomy. Conclusion: Estrogen decreases food intake, it decreases sensitivity of female rats to hypophasic effects of Naloxone. Testosterone decreases food intake. Testosterone does not interfere with hypophagic effect of Naloxone.
Authors and Affiliations
Gargate Ashwini R| Associate Professor, Department of Physiology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India, Corresponding author email: ashwinigargate@yahoo.in, Kulkarni Dushant V| M. Sc (Med Physiology) Student, Department of Physiology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India
Keywords
Related Articles
- EP ID EP11143
- DOI -
- Views 333
- Downloads 13
SYNCHRONOUS OCCULT METASTASISING DUODENAL CARCINOID AND OVARIAN MUCINOUS CYSTADENOCARCINOMA – MULTIPLE PRIMARY MALIGNANCIES IN THE SAME PATIENT
Gastrointestinal carcinoid tumors are uncommon neuroendocrine tumours that may be associated with synchronous or metachronous primary tumours of other histological type, most frequently colorectal adenocarcinomas. Prima...
PROPERTIES OF A HIGH RATE OF MRSA COLONIZATION IN THE NASAL CAVITY OF INTENSIVE CARE UNIT DOCTORS
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major causative agent of healthcare-associated infections. Aims: To survey S. aureus/MRSA colonization in the nasopharyngeal cavities of intensive ca...
Assessment of patient safety culture in viewpoints of Kashan hospitals nurses 2016
Patient safety, i.e. prevention of any hurt to the patient, is one of the main factors of health care quality. Improving patient safety culture through the implementation of systems and processes necessary to work can p...
The investigation of the infected hunted mice in Karandish and Kaveh terminals of Shiraz to Leishmaniasis with PCR method in 2015
Leishmaniasis, is one of the common diseases among humans and animals caused by different species of protozoa of the Leishmania genus species and is seen in three forms of cutaneous, mucocutaneous and visceral Leishmani...
A STUDY TO ANALYZE THE PREVALENCE OF MARTIN GRUBER ANASTOMOSES AMONG MEDICAL STUDENTS
The most frequently occurring anomaly in the upper extremities has been the Martin Gruber Anastomoses (MGA) which occurs due to the crossover of nerve fibers from the median nerve to ulnar nerve. This study was perform...