Effect of gonadotropins versus a selective estrogen receptor modulator on ovulation in anovulatory women.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 5
Abstract
Background : Anovulation and oligo-ovulation are ovulatory disorders that are estimated to cause 21% of female. Over the past several years, new developments have occurred in ovulation induction therapy. These developments, which include new information relevant to established methods of inducing ovulation. Pulsatile GnRH has been used with less success in WHO Group II anovulatory women. Clomiphene citrate and FSH are the agents of choice for ovulation induction therapy in Group II women. FSH may be an appropriate first line treatment for some women with PCO and anovulatory infertility particulary older patients. Aim of the study: This study was designed to compare the effect of starting with gonadotropins versus clomiphene citrate cc(selective estrogen receptor modulator) on ovulation in anovulatory women. Material &Methods: a case-control study include 40 patients anovulatory(regular and irregular cycles) and want pregnancy attended to outpatient clinic in Suez Canal university hospital. Two groups of patients anovulatory, group (1) 20 patients starting with cc in 2nd day of cycle 100 mg daily for 5 days then complete from 7th day with FSH till dominant follicle DF 18 mm or more. And group (2) 20 patients starting with FSH 75 IU in 2rd day of cycle for 4 days then complete from 6th day with cc till dominant follicle DF 18 mm or more. Folliculometry, Serum medluteal progesterone, E2, FSH and LH done for every patient Results. In this study we found that ovulation rate was higher in G2 than in G1 Also early ovulation was significant in G2 than in G1 Conclusion. The results suggest that it is more effective to start with gonadotropins versus clomiphene citrate in anovulatory women on ovulation and as a cost effective regimen.
Authors and Affiliations
Dalia Ibrahim MD, Mohamed Abdo MD, Nadia Abozied MD Hanan Ghoniem MD
Keywords
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- EP ID EP563159
- DOI 10.22192/ijcrms.2018.04.05.007
- Views 120
- Downloads 0
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