Effect of Hemodialysis on Oxidative Stress on Diabetogenic Patient of Chronic Renal Failure
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
Free radicals are highly reactive molecules generated by biochemical redox reactions that occur as a part of normal cell metabolism. Advance glycations end products in diabetes also give rise to free radicals, which shift the balance in favour of prooxidant resulting in oxidative stress which is present in diabetogenic chronic renal failure patients undergoing hemodialysis. Hemodialysis can control uremia, reduce hypotensive episode, resolves acute renal failure rapidly and lowers the mortality significantly. The objective of the study was to estimate and compare markers of oxidative stress (Malondialdehyde, Glutathione peroxidise and Vitamin C) in pre and post hemodialysis patients. Fifty diabetic patients diagnosed as per criteria of American Diabetic Association, under going hemodialysis, were selected for the study after obtaining the ethical clearance from the institute. Levels of MDA, GPx and Vitamin C were estimated before and after hemodialysis. We observed that MDA levels were significantly raised in post hemodialysis as compared to pre www.jmscr.igmpublication.org Impact Factcor-1.1147 ISSN (e)-2347-176x Effect of Hemodialysis on Oxidative Stress on Diabetogenic Patient of Chronic Renal Failure Authors Ashish Shukla1 , Akash Gupta2*, Naved Ahmad3 1 Assistant Professor, Department of Biochemistry, Subharti Medical College, Meerut, U.P. 2* Assistant Professor, Department of Biochemistry, Rama Medical College, Hapur, U.P. 3 Phd Scholar, Department of Biochemistry, Subharti Medical College, Meerut, U.P. *Corresponding author Dr Akash Gupta Department of Biochemistry, Rama Medical College Pilakhua -245304, Hapur, U.P. India Email - akash_inspace@yahoo.com Ashish Shukla et al,JMSCR Volume 2 Issue 4 April 2014 Page 615 JMSCR Volume||02||Issue||04||Page 614-620||April 2014 2014 hemodialysis (p < 0.001) while glutathione peroxidise and vitamin C levels were significantly lower in post hemodialysis as compared to pre hemodialysis. As their is consumption of antioxidants by over production of free radicals/ reactive oxygen species in hemodialysis, levels of malondialdehyde, glutathione peroxidise and vitamin C can lead us more close to new approaches for improvement in hemodialysis membranes and its techniques and also exogenous supplementation of antioxidant for removal of free radicals.
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Dr Akash Gupta
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