EFFECT OF HISTAGLOBULIN IN ALLERGIC RHINITIS- A PROSPECTIVE STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 50
Abstract
BACKGROUND Rhinitis can be defined as congestion of Nasal Mucous Membrane accompanied by Rhinorrhoea and Sneezing. Two elements required for its development are an immunological sensitivity to an allergen and recurrent continuous exposure to it resulting in Histamine release. Histaglobulin Subcutaneous Injection leads to development of Antibodies to Histamine which will protect for 6 to 18 months against endogenous Histamine released as a result of allergy. The aim of our study was to evaluate the effect of histaglobulin in improving the symptomatology and quality of life of patients suffering from allergic rhinitis, not responding to conventional treatment modalities. MATERIALS AND METHODS A study of 50 patient aged 16 to 50 years of Allergic Rhinitis was conducted in ENT Department of GSVM Medical College, Kanpur for a period of 18 months. Subcutaneous histaglobulin injection was given in doses of 1 ml, 4 Injections at an interval of 4 days for first month, next 4 injections at interval of 4 days in next month, followed by 1 injection per month for the next 3 consecutive months and booster dose after 6 months was given. RESULTS The effectiveness of Histaglobulin was evaluated by history, clinical examination, allergic tests like serum IgE estimation and eosinophil count to assess the response to therapy. 23 patients had complete response, 21 had fair response, while 6 had a poor response. CONCLUSION Histaglobulin injection is safe and effective treatment for Allergic Rhinitis with no adverse effects. It gives promising results for considerable periods of time, improves the quality of life in allergic rhinitis patients.
Authors and Affiliations
Abhinav Verma, Anveksha Sachan, Aditi Singh, Swetlana Sachan
Keywords
Related Articles
- EP ID EP607641
- DOI 10.18410/jebmh/2018/695
- Views 140
- Downloads 0
A STUDY OF FOREIGN BODIES IN THE CRICOPHARYNGEAL REGION AND OESOPHAGUS IN A TRIBAL REGION OF CHHATTISGARH
BACKGROUND Foreign body in the food passage is a common problem; but piercing foreign bodies in the food passage may cause fatal complications like retropharyngeal abscess, pneumothorax, ulcerative oesophagitis, pneumoni...
A COMPARATIVE STUDY OF PREOPERATIVE DIAGNOSIS AND PATHOLOGICAL DIAGNOSIS IN ADRENAL SWELLINGS
BACKGROUND The adrenal gland neoplasms include primary and metastatic malignant tumours. They can be functional or non-functional and also detected as incidentaloma lesions. Advanced imaging often reveals adrenal tumours...
PREVALENCE OF SUBSTANCE ABUSE AMONG ADOLESCENTS AND YOUNG ADULTS IN RURAL BANGALORE- AN EPIDEMIOLOGICAL STUDY
BACKGROUND According to world drug report, youth from urban settings have been topping the charts for drug abuse. The alarming rate of drug abuse and especially the increase of drug abuse among youngsters has had detrime...
A COMPARATIVE STUDY OF CENTRAL FOVEAL THICKNESS PRE AND POST CATARACT SURGERY USING SD-OPTICAL COHERENCE TOMOGRAPHY
BACKGROUND The purpose of this study is to compare central foveal thickness (CFT) of patients preoperatively and postoperatively cataract surgery using SD- optical coherence tomography and to correlate CFT with vision. M...
FUNCTIONAL OUTCOME OF CORE DECOMPRESSION WITH FIBULAR GRAFTING IN THE MANAGEMENT OF AVASCULAR NECROSIS OF THE FEMORAL HEAD
BACKGROUND Avascular necrosis of the femoral head is a condition affecting people between ages 30 and 50 years, most often bilateral. Core decompression with bone grafting is a commonly done procedure in early stages of...