Effect of HIV Infection and Antiretroviral Therapy Duration on Reticulocyte Count and Red Cell Indices
Journal Title: International Blood Research & Reviews - Year 2014, Vol 2, Issue 4
Abstract
Aim: To determine the Red cell indices and Reticulocyte count values in HIV-positive patients under antiretroviral treatment and those not under antiretroviral treatments with varying durations of HIV infection and antiretroviral treatments. Study Design: Case-control study. Place and duration of Study: The study was carried out at Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria from March to August 2013. Methodology: 181 subjects were recruited consisting; Sixty (30 males and 30 females) HIV subjects under antiretroviral therapy (ART) with an HIV infection and ART duration of <1–5 years, >5 –8 years and >8–17 years; Sixty (25 males and 35 females) HIV subjects not under ART (non-ART) with an infection duration of <1–3 years, >3–6 years and >6–11 years; and Sixty-one (31 male and 30 female) apparently healthy seronegative control subjects. The Reticulocytes count, Packed cell volume (PCV), Haemoglobin (HGB), Red blood cell count (RBC), Mean cell volume (MCV), Mean cell haemoglobin (MCH), Mean cell haemoglobin concentration (MCHC) and Human Immunodeficiency virus (HIV) status of the study subjects were determined. Results: MCV and MCH for ART and non-ART subjects were significantly increased compared with control group (P<.05) and the differences with varying durations of HIV infection and antiretroviral therapy were not significant (P>.05). Moreover, there was a significant decrease in the mean HGB, RBC, MCHC of ART and non-ART compared with control (F=8.51; 133.85; 33.32; P<.05 respectively) and their differences with varying durations of infection and antiretroviral therapy were not significant (P>.05). MCV were significantly higher in ART compared with non-ART (P<.05). Conclusion: There is no significant variation in Red cell indices and Reticulocyte count values in HIV patients with differences in duration of HIV infection and antiretroviral therapy.
Authors and Affiliations
Chizoba Okechukwu Okeke, Grace I. Amilo, Martin Ifeanyichukwu, Ogochukwu M. T. B. Ochiabuto, Anulika O. Onyemelukwe, Sylvester Nnaemeka Ibekailo
Keywords
Related Articles
- EP ID EP242544
- DOI 10.9734/IBRR/2014/10243
- Views 120
- Downloads 0
Iron Overload, Chelation Therapy and Survival in Lower-Risk Myelodysplastic Syndromes: State of the Evidence
Myelodysplastic syndromes (MDS) are clonal stem cell disorders that primarily affect older persons and are associated with peripheral blood cytopenias, increased risk of conversion to acute myeloid leukemia and shortened...
Early Diagnostics of Beta Thalassemia Minor
Early diagnosis of disease is highly recommended for the treatment purposes by the clinicians. Thalassemia is a genetic disorder which can be inherited from the parents. Thalassemia is classified into two groups alpha th...
In vitro Anti-erythrocyte Sickling Effect of Lunularic Acid of Natural Origin
Aims: To evaluate the antisickling activity of lunularic acid. Study Design: Biological experiment in vitro (Emmet test), evaluation of cell morphological parameters such as radius, perimeter and surface. Place and Durat...
Atrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012
Aims: is to correlate the atrial function with the level of oxidative stress marker (Glutathione) in children with Iron deficiency anemia (IDA). Materials and Methods: Thirty children with IDA and 20 healthy children ha...
In vitro Study of Antioxidant and Anticoagulant Activities of Ethanol Extract of Pandanus tectorius Leaves
Pandanus tectorius of the family Pandanaceae is a medicinal plant that grows in Nigeria. The Pandanus tectorius extract was tested for; its acute toxicity using mice and, its antioxidant activities (using DPPH spectromet...