Effect of Inj. Dexmedetomidine and Inj. Clonidine on Haemodynamic Changes during Laryngoscopy &Tracheal Intubation: A Comparative Study
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 4
Abstract
Aim and Objectives: 1. To evaluate the effects of dexmedetomidine and clonidine on haemodynamic changes during Laryngoscopy and tracheal intubation. 2. To compare the effect of dexmedetomidine and clonidine on haemodynamic changes during Laryngoscopy and tracheal intubation. 3. To compare the side effects. Materials & Methods: After approval of the institutional ethical committee, this prospective observational study was conducted on 60 patients of ASA Grade I & II , undergoing elective surgeries under general anesthesia. Group A: Injection Dexmedetomidine 1mcg/kg diluted to 20ml with normal saline were given over 10 minutes. Group B: Injection. Clonidine 2mcg/kg diluted to 20ml with normal saline were given over 10 minutes. All patient received Injection Pentazocine 0.3mg/kg and were pre-oxygenated for 3minute Anaesthesia was induced with thiopantone sodium (5mg/kg intravenous) till loss of eyelashreflex over 30 second and mask ventilation was confirmed. Injection succhinylcholine 1.5mg/kg was given to facilitate laryngoscopy and intubation. anaesthesia was maintained with oxygen nitrous oxide, halothane with intermittent use of injection Atracurium and controlled ventilation. At the end of surgery the neuromuscular blockade was antagonized with injection Glycopyrolate (.01mg/kg) Intavenou. and injection Neostigmine (.05mg/kg) i.v. and patient were extubated. Result: Dexmedetomidine is more effective than Clonidine in attenuation of haemodynamic changes during laryngoscopy and intubation. Conclusion: Dexmedetomidine significantly attenuates the haemodynamic changes during laryngoscopy and intubation. Clonidine also significantly attenuates the haemodynamic changes during laryngoscopy and intubation.Thus we conclude that Dexmedetomidine is a better drug to attenuate the haemodynamic response during laryngoscopy and intubation.
Authors and Affiliations
Abhay Raj Yadav
Keywords
Related Articles
- EP ID EP535386
- DOI 10.21088/ijaa.2349.8471.5418.4
- Views 78
- Downloads 0
A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries
Background: Subarachnoid block is popular and commonly used worldwide. The advantage of an awake patient, minimal drug cost and rapid patient turnover has made this the method of choice for many surgical procedures. Amon...
Are We Performing Hand Hygiene: A Lifesaving Skill Correctly?
This question is asked invariably just like being asked during CPR’s correct method and right timing of practicing hand hygiene to avoid a loss of life to hospital acquired infection (HAI). Are we doing enough? Are we re...
A Comparision between Femoral Nerve Block, Intravenous Fentanyl and Ketamine as Preemptive Analgesics in Lower Limb Fractures
Background: Spinal & combined spinal epidural anaesthesia are the preferred techniques for facilitation of surgical fixation of the fractures of the lower limb. Extreme pain does not allow ideal positioning for these pro...
Dexmedetomidine an Adjuvant in Anaesthesia for Functional Endoscopic Sinus Surgery (FESS)
Dexmedetomidine can provide controlled hypotension, analgesia, and sedation. The present study aimed to evaluate advantages of dexmedetomidine as an adjuvant in anesthesia fo FESS (Functional Endoscopic Sinus Surgery). M...
Comparison of Bilateral Superficial Cervical Plexus Block and Incision Line Infiltration for Postoperative Analgesia for Thyroid Surgeries Under General Anesthesia
Introduction: Thyroid surgeries are usually performed under general anesthesia as it involves manipulation of the trachea.Studies comparing bilateral superficial cervical plexus block and incision line infiltration for p...