EFFECT OF LIPIDS ON PHYSICOCHEMICAL PROPERTIES OF LETROZOLE LOADED SOLID LIPID NANOPARTICLES
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2016, Vol 8, Issue 5
Abstract
The objective of the current investigation was to prepare solid lipid nanoparticles (SLNs) from different lipids and to study the effect of lipids on physicochemical characteristics of letrozole loaded SLN. In order to prepare small, stable, uniform and high Letrozole loaded SLNs, many factors such as lipid and stabilizer concentration and preparation parameters can be considered. Out of these, we have selected solid lipid as lipid matrix to investigate an effect on SLNs. SLNs were prepared using different lipids by modified hot sonication method. The effect of different lipids and stabilizers on physicochemical characteristics of Letrozole loaded SLNs were investigated. Letrozole loaded SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, SLN1 showed biggest particle size (532.5 ± 26.4nm) and highest encapsulation efficiency (81.37 ± 6.72%) and, SLN4 showed highest cumulative drug percentage (89.4 ± 1.8%, 24 h) release. These results suggest that lipids type affect physicochemical properties and release profile of SLN. The choice of lipid and stabilizer played important role on the physicochemical characteristics and in vitro release of Letrozole loaded SLNs.
Authors and Affiliations
Archana Nerella, Basava Raju Dontamsetti, Aruna Devi Mantena
Keywords
Related Articles
- EP ID EP625196
- DOI 10.25004/IJPSDR.2016.080501
- Views 84
- Downloads 0
FORMULATION AND EVALUATION OF NASAL NIOSOMAL IN SITU GELS OF LORATADINE
Loratadine is an antihistaminic drug, used in the treatment of allergic inflammation. Poor bioavailability of the drug from conventional dosage forms is especially attributable to mucociliary clearance and transient resi...
ANALYTICAL METHOD VALIDATION OF AN HERBAL FORMULATION BY HEADSPACE GAS CHROMATOGRAPHY USING QBD
Essential oils are rich sources of biologically active compounds possessing diverse medicinal properties. These form integral part of a number of herbal formulations. The most challenging part of commercialization of her...
AN OVERVIEW OF STATINS AS HYPOLIPIDEMIC DRUGS
There is a wealth of evidence suggesting association between Dyslipidemia and Heart Failure. Statins are the treatment of choice for the management of Dyslipidemia because of their proven efficacy and safety profile. The...
DENDRIMERS AS A POTENTIAL DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW
Dendrimers are synthetic, highly branched, monodisperse macromolecules of nanometer dimensions with exact and large number of functional groups, distributed with unprecedented control, makes them a promising scaffolds, f...
DETERMINATION OF BIOACTIVE COMPONENTS OF ETHYL ACETATE FRACTION OF PUNICA GRANATUM RIND EXTRACT
Punica granatum belongs to a Punicaceae family. The Punica granatum is valued as a powerful medicinal plant and used in folk medicines. Hence the present investigation was carried out to determine the possible chemical c...