Effect of Maternal Protein Restriction during E10&11 Day of Gestation on Organ Weights, Litter Size, Placental Weight and Biochemical Analysis
Journal Title: Indian Journal of Nutrition - Year 2016, Vol 3, Issue 2
Abstract
Environmental constraints during pregnancy results in phenotypic changes which will be associated with changes in biochemical components and alteration in body and placentae weight. The aim of the study is to investigate the effect of maternal protein restriction during embryonic day 10 (E10) and 11 (E11) (Acute protein restriction). Pregnant mice were divided into four groups (I-IV) respectively. Pregnant mice were fed on 10th and 11th day with isocaloric low protein diets (control diet 24% diet for group I, 18% diet for group II, 12% diet for group III and 6% diet for group IV) and studied at gestational day 18. Maternal body weight, visceral organ and reproductive organ weights, litter size, placental number and biochemical parameters were analyzed. The levels of various biochemical parameters including serum glucose, urea, uric acid, creatinine, cholesterol, HDL, LDL, TGL, VLDL, bilirubin (total, indirect and direct) showed significant variations (P˂0.05) when compared to those of the control group. Similarly, SGPT, SGOT, total protein and albumin levels increased significantly in protein restricted groups, when compared with group I, whereas the body weight and organ weights showed no significant change. Among the restricted groups, group IV shows 5.0771 ± 0.128 g, group III 5.439 ± 0.059 g, group II 55.2501 ± 0.026 g and control group I with 5.5056±0.0341 g of placenta weights. While the weights of fetuses in group I26.81 ±2.993, group II 13.76 ±0.211, group III 18.3±2.151 and group IV 16.16 ±1.970 g shows reduction in placental weights. We demonstrated the effect of maternal protein restriction during 10 and 11th day of gestation, which influences the change in the visceral organ weight and reproductive organ weight. Our observation coincides with the earlier findings which showed that the increase in the blood glucose in the restricted group paved way for the development of Diabetes in the adult life and showed lower fetal weight and placental weight in the restricted groups.
Authors and Affiliations
A Benno Susai Vijayakumar
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