Effect of Matrine Injection Combined with First-line Chemotherapy in the Treatment of Lung Cancer: a Meta-analysis
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2017, Vol 7, Issue 5
Abstract
The aim of this study is to systematically evaluate the efficacy and safety of matrine injection (MI) combined with first-line chemotherapy in the treatment of lung cancer. The search was applied to Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, WANFANG DATA, VIP and CBM database from 2006 to 2016. Randomized controlled trials (RCTs) of MI combining first-line chemotherapy (versus chemotherapy alone) in any language were included. Two authors extracted data and assessed literature quality independently. Meta-analysis was conducted by using RevMan 5.3 software. Ten studies total 906 cases were included. The meta-analysis showed that compared with the first-line chemotherapy alone, the combination of MI and first-line chemotherapy in the treatment of lung cancer could not only improve the short-term clinical efficacy [RR = 1.17, 95% CI (1.02, 1.34), P = 0.02], complete response (CR) [RR = 1.46, 95% CI (0.99, 2.15), P = 0.06] and the quality of life [RR = 1.62, 95% CI (1.19, 2.20), P = 0.002], but also reduce WBC toxicity [RR = 0.39, 95% CI (0.27, 0.55), P < 0.00001] and the nausea and vomiting [RR = 0.52, 95% CI (0.37, 0.73), P = 0.0002]. Matrine injection combined with first-line chemotherapy regimen for lung cancer has a certain synergistic effect, but it needs to be further confirmed through a large sample of clinical studies
Authors and Affiliations
Yizhen Zhang, Haihua Guo, Guohua Cheng
Keywords
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