Effect of Metformin on Serum Thyrotropin (Thyroid Stimulating Hormone) Levels in Hypothyroid Patients on Stable and Adequate Levothyroxine Doses with Diabetes or Pre- Diabetes
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 6
Abstract
Aims: To assess the effect of metformin on serum thyrotropin (thyroid stimulating hormone) levels in hypothyroid patients on stable and adequate levothyroxine doses with diabetes or prediabetes. Settings and Design: Prospective clinic based study Methods and Material: Total 80 patients age more than 18 years, diagnosed hypothyroid, adequate and stable LT4 replacement therapy, type 2 diabetes or prediabetes, only on metformin along with diet and life style modification for blood sugar control were studied over a period of 12 months. In control group, patients received adequate and stable supplementation of LT4 without metformin. Serum TSH values at baseline, after three months, six month and 12 months were analysed. Statistical analysis used: Unpaired t-test to find significant difference in the baseline and follow-up study parameters namely LT4 and TSH between two groups. Repeated measure ANOVA was used to observe the within group differences for the changes in LT4 and TSH. Results: In study group, after three, six & 12 months of on metformin, mean TSH was significantly lower than basal TSH, p < 0.0001 for all time points. Mean free T4 (FT4) level changes were nonsignificant in three month, but significantly increased after six & 12 months of metformin administration, p=0.691,p=0.007, and p=0.001 respectively) whereas non-significant changes in mean TSH and mean FT4 in control group. Conclusions: Treatment with metformin is associated with significant reduction in the serum TSH levels. TSH reduction is not associated with reciprocal changes in FT4 at three months but at six months and 12 months and is associated with significant increase of FT4 in primary hypothyroidism patients on stable and adequate levothyroxine doses who were found to have diabetes or prediabetes.
Authors and Affiliations
Anirban Sinha, Kingshuk Bhattacharjee, Pulakesh Sinha, Aditya Verma, Ashesh Halder
Keywords
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- EP ID EP333707
- DOI 10.15226/2374-6890/3/6/00166
- Views 98
- Downloads 0
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