EFFECT OF METHANOL, N-HEXANE AND AQUEOUS EXTRACT OF PSIDIUM GUAJAVA LEAF ON CASTOR OIL-INDUCED DIARRHOEA IN ALBINO RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 9
Abstract
Paw paw leaf (Psidium guajava) is commonly used locally to treat diarrhoea. The present study evaluated the anti-diarrhoea effect of this plant extract on albino rats induced with castor oil. Fresh tender leaf of this plant was collected, air-dried, powdered and percolated in n-hexane, methanol and aqueous solvents. Diarrhoea was induced with castor oil on albino rats using standard procedures. The extract (100, 250 and 500 mg/kg) in a dose dependent manner, significantly protected the rat against diarrhoea induced experimentally with castor oil in terms of nature and number of stool droppings within 3hrs of administration of extract, there was no significant difference when compared with the control drug (Loperamide) (P > 0.05). The study justifies the ethno pharmacological uses of this medicinal plant for treatment of diarrhoeal disease.
Authors and Affiliations
Unaeze Bright Chukwuebuka
Keywords
Related Articles
- EP ID EP629015
- DOI -
- Views 151
- Downloads 0
GC-MS IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM SOLVENT EXTRACTS OF DIOSPYROS FERREA (WILLD.) BAKH, LEAF
The present study was investigated forty phytocompounds in polarity based solvents that is Hexane, Ethylacetate and methanolic leaf extract of Diospyros ferrea (Ebenaceae). These compounds are proved to be antidiabetic a...
ASSOCIATION OF IRON DEFICIENCY AND HELICOBACTER PYLORI INFECTION IN THE KHARTOUM STATE -2018
Background: Iron deficiency defined as decrease total body iron content, is more the most common nutritional deficiency in the world, iron deficiency related to impairment in immune infection, such as H. pylori Aim: The...
OYSTER MUSHRROM CULTIVATION AT DIFFERENT PRODUCTION SYSTEMS: A REVIEW
This paper aims to review historical perspectives, nutritional and medicinal benefits, biodiversity, cultivation, diseases and their control, pathogen detection systems, food safety concerns and use of spent mushroom com...
INVESTIGATIVE STUDIES ON THE EFFECTS OF ETHANOL ROOT EXTRACT OF DENNETTIA TRIPETALA ON LIVER ENZYMES, PROTEIN AND BILIRUBIN LEVELS IN WISTAR RATS ADMINISTERED THERMOXIDIZED PALM OIL
This study investigated the effect of ethanol root extract of Dennettia tripetala on liver enzymes, protein and bilirubin level in wistar rats administered thermoxidized palm oil. Twenty wistar rats divided into 4 groups...
EVALUATE THE ASSOCIATION BETWEEN OTALGIA, TINNITUS AND TEMPOROMANDIBULAR JOINT DYSFUNACTION
Background: The temporomandibular joint is closely related anatomically to the external acoustic meatus and clinical conditions of the joint may produce symptoms of pain that must be distinguished from those directly ass...