EFFECT OF METHYL-Î’-CYCLODEXTRIN COMPLEXATION ON THE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF KHELLIN: EXPERIMENTAL STUDY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 11
Abstract
Objective: The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-β-cyclodextrin (MβCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects.Methods: Inclusion complexes of KH-MβCD in the presence of water-soluble polymer were prepared by freeze drying (FD), co-evaporation (EV) and kneading methods (KN). The selected ternary complex was characterized by Fourier transform infrared spectrophotometry (FTIR), x-ray diffractometry (XRD), differential scanning calorimetry (DSC) and scanning electron microscopy [1]. Assessment of the hypoglycemic effect of the selected ternary complex versus the standard drug metformin was studied. Two different doses of the ternary complex were administered orally to streptozotocin (STZ)-induced type 2diabetic rats. Their hypoglycemic and hypolipidemic effects were evaluated by measuring the fasting blood glucose level (BGL), total cholesterol (TC) and triglycerides levels (TG) along the study period.Results: The FD complex showed the highest drug dissolution rate. All the performed characterization analysis confirmed the formation of a KH-MβCD inclusion complex. The in vivo study declared that both doses showed a marked hypoglycemic and hypolipidemic effects compared to metformin.Conclusion: In conclusion, this study points for the first time that the complexation of KH with MβCD could notably improve the dissolution rate and hence the bioavailability of KH. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment in type 2 diabetes mellitus (T2DM).Â
Authors and Affiliations
Mona M. Abousamra, Mona Basha, Sally El Awdan, Nasser S. M. Ismail
Keywords
Related Articles
- EP ID EP575902
- DOI 10.22159/ijpps.2016v8i11.14365
- Views 103
- Downloads 0
EFFECTIVE MANAGEMENT OF HEMOLYTIC COMPLICATIONS BY TRADITIONALLY PREPARED KÄ€NTAM FORMULATIONS
Objective: KÄntam based formulations are unique herbo-metallic preparations, used in Siddha system of medicine (Indian traditional medicine) for managing various haematological complications. Their therapeutic doses wer...
DESIGN AND EVALUATION OF CONTROLLED-RELEASE OCULAR INSERTS OF BRIMONIDINE-TARTRATE AND TIMOLOL MALEATE
Objective: The current work was attempted to formulate and evaluate a controlled-release matrix-type ocular inserts containing a combination of brimonidine tartrate and timolol maleate, with a view to sustain the drug re...
RNAI MEDIATED GENE SILENCING OF EIF3A: A POSSIBLE SOLUTION TO CONTROL BREAST CANCER
Objective: The eukaryotic translational initiation factor 3A (eIF3A) is reported to be over expressed in most breast cancer cells. In the present study, our aim is to suppress the over expression of eIF3A in human breast...
PHARMACOLOGICAL EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC EFFECTS OF GYNOCARDIA ODORATA ROXB IN ANIMAL MODELS
Objective: The purpose of this investigation was to study the anti-inflammatory, analgesic, and antipyretic properties of methanol extract of Gynocardia odorata roxb (MEGO) in rats and mice.Methods: The plant material wa...
THE STABILITY OF GENERIC MEROPENEM IN TROPICAL COUNTRIES
Objective: To evaluate the stability of two brands of generic meropenem at high ambient temperatures and various concentrations in solution.Methods: Generic meropenem brand A and brand B vials were used to prepare 10 mg/...