Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 3
Abstract
Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg(2+) seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg(2+). These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.
Authors and Affiliations
Elena Isaeva, Irina Lushnikova, Alina Savrasova, Galina Skibo, Gregory Holmes, Dmytro Isaev
Keywords
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