Effect of Perioperative Intravenous Infusion of Lignocaine on Haemodynamic Responses to Intubation, Extubation and Post Operative Analgesia
Journal Title: Asian Pacific Journal of Health Sciences - Year 2017, Vol 4, Issue 2
Abstract
Background: Intravenous bolus dose of lignocaine is generally used to reduce haemodynamic changes associated with intubation and extubation. Whereas lignocaine intravenous infusion has been used for post‑operative analgesia. Aims and Objectives: To evaluate the effect of peri-operative intravenous infusion of lignocaine on hemodynamic responses to intubation, extubation and post-operative analgesia. Materials and Methods:80 patients undergoing elective laparoscopic cholecystectomy were included in our study and they were randomly divided into two groups, Group A and B of 40 each. Group A patients received 6 ml normal saline as bolus over 10 minutes followed by 6 ml/hour infusion, whereas in Group B, patients received preservative free 2% lignocaine 1.5 mg/kg IV bolus (made to a volume of 6 ml with normal saline) administered over a period of 10 minutes and thereafter an infusion at a rate of 1.5 mg/kg/hour (pre‑diluted in normal saline made to a volume of 6 ml/hour. P < 0.05 was considered as significant. Results: Group B patients showed significantly longer mean pain‑free post‑operative period and also a less rise in pulse rate and mean arterial pressure compared to the Group A (P < 0.05) during intubation and extubation. Conclusion: Lignocaine infusion can successfully avert the change of haemodynamics resulting from intubation and extubation.
Authors and Affiliations
Dr. . Trivikram N
Keywords
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- EP ID EP525404
- DOI 10.21276/apjhs.2017.4.2.4
- Views 161
- Downloads 0
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