EFFECT OF PHAFFIA RHODOZYMA BIOMASS AND ANTIOXIDANTS ON THE ENZYMES OF GLUTATHIONE SYSTEM IN THE TISSUES OF ALBINO RATS UNDER AFLATOXIN B1 INFLUENCE
Journal Title: Наукові доповіді НУБіП України - Year 2017, Vol 3, Issue 3
Abstract
Prevention of aflatoxin B1 (AFB1) poisoning in animals is one of important problems in animal husbandry and veterinary medicine. The results presented in this article show the influence of yeasts Phaffia rhodozyma biomass, vitamin E and "E-Selenium" preparations on the enzymes of glutathione system and content of reduced glutathione (GSH) in the liver, brain and kidney tissues of albino rats in conditions of daily administration of AFB1 (0.025 mg/kg, for 14 days). The introduction of AFB1 leads to inhibition of glutathione peroxidase and glutathione reductase activities, and decreases GSH concentration in studied tissues. The use of Phaffia rhodozyma biomass (1.5 g/kg body weight daily) against AFB1 toxicity causes normalization of enzyme activities and GSH concentration in rats’ liver, brain and kidney tissues on the 14th day of experiment. Intramuscular injection of "ESelenium" (0.05 ml/kg body weight) or intragastric E vitamin administration (100 mg/kg body weight) to the rats exposed to AFB1 caused an increase in the activities of glutathione reductase and glutathione peroxidase, and GSH content in rat tissues on the 7th day compared to those indices in animals treated only with AFB1. However, positive effect of antioxidants in the conditions of AFB1 toxicity was not apparent on the 14th day of experiment. Thus, the daily introduction of yeasts Phaffia rhodozyma biomass as additive to the diet of rats (1.5 g/kg body weight daily) can exert more effective protective effect in comparison to single application of vitamin Е or “E-Selenium” preparations in animals exposed to AFB1.
Authors and Affiliations
N. K. Hoivanovych, H. L. Antonyak
Keywords
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