Effect of Pharmacological treatment on cardiac biomarkers in patients with acute coronary syndrome of non–ST segment elevation with Type-2 diabetes
Journal Title: International Journal of Medical and Health Sciences - Year 2016, Vol 5, Issue 1
Abstract
Background: The acute coronary syndrome is a consequence of coronary artery disease. Creatine Kinase MB is a cardiac biochemical marker used in the diagnosis and risk stratification of patients. The diabetes is a pathology associated to acute coronary syndrome non–ST segment elevation that change the cardiac conditions, in this sense, our objective was to evaluate the modifications of cardiac biomarkers values in diabetic patients. Materials and methods: A retrospective study included 155 patients of both sexes, ages ranging from 31 to 92 years old, admitted to the coronary unit of the “Reina Fabiola” Clinic, Córdoba, Argentina was performed in the period 2014-2015. Body mass index, time consultation pain, plasmatic Creatine Kinase isoenzyme MB activity and Troponin I levels were measured. The patients were stratified into two groups: without cardiovascular risk pathologies (Control group), n = 7; and with only type II diabetes, n = 64 treated with therapeutic doses of metformin (n= 37), and glibenclamide plus glizipide (n= 27). Results: cTnI levels were lower in both pharmacological treatments at 12 hrs when the values in control reach the highest. Similarly, CK-MB activity was lower at 8 hrs in both treatments; however at 12 hrs these values were lower only with metformin but not in glibenclamide plus glizipide treatment. These results could be showing an interaction between diabetes and pharmacological treatment upon the biomarkers values. Conclusion: The use of hypoglycemic drugs and the glycometabolic state are conditions that could modify CK-MB and cTnI release/clearance balance at 8 and 12 hrs after admission to the coronary unit.
Authors and Affiliations
AgustÃn N. JOISON, Gustavo BAIARDI
Keywords
Related Articles
- EP ID EP39941
- DOI -
- Views 265
- Downloads 0
Tumoral Calcinosis - A case report
Tumoral calcinosis is a distinct clinical and histologic entity that is characterized by tumour like periarticular deposits of calcium that are found foremost in regions of hip, shoulder and elbow. The disorder occurs p...
Antioxidants and Serum Uric Acid levels in Post-Stroke Cases
Background: Measurement of antioxidants and serum uric acid in post-stroke cases is very important because they may play a role in the prevention of stroke and its deleterious effects as they scavenge free radicals and...
Viva Voce: Has It Outlived Its Utility?
Abstract:Introduction: Undergraduate teaching and assessment is under the scanner for a makeover. There is a need to change. Medical schools all over the world are advocating the need to move from the traditional methods...
Double toothed mandibular third molar – A rare anomaly – case report
Abberantmorphoanatomy of tooth are not uncommon, like fusion,gemination, concresence, dilacerations, talons cusp, dens in dente, dens evagenatus, taurodontismand supernumerary tooth. But gemination or fusion of mandibul...
Analysis of Road Traffic Accidents in Kurnool City
Background: In road traffic, risk is a function of four elements. The main risk factors for road traffic injuries are- Factors influencing exposure to risk, Risk factors influencing crash involvement, Risk factors influ...