Effect of Sodium Valproate and Docosahexaenoic Acid on Pain in Rats
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient’s consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity. We planned a study to assess the effect of sodium valproate alone and in combination with DHA in rat models of pain. Aim: To evaluate the analgesic activity of sodium valproate and DHA supplementation using various experimental models in albino Wistar rats. Materials and Methods: For analgesic activity, A total of 48 adult Wistar albino rats were divided into eight groups of six rats each. Group I was control (distil water 1 ml/kg), Group II received intraperitoneal injection of tramadol (10 mg/kg), Group III, IV, V were injected intraperitoneal sodium valproate 100, 200, 400 mg/kg with distil water respectively and Group VI, VII, VIII were given sodium valproate 100, 200, 400 mg/kg plus DHA 300 mg/kg (intraperitoneal) respectively. Analgesic activity was assessed using hot plate, tail flick and acetic acid writhing models. Results: We found that sodium valproate at higher doses (400 mg/kg) used either alone along with DHA (300 mg/kg) showed statistically significant analgesic activity in comparison to control in various experimental models for assessing pain. Conclusion: Combination of sodium valproate along with DHA has shown promising analgesic activity.
Authors and Affiliations
Sushil Kiran Kunder, Laxminarayana Kurady Bairy, Avinash Arivazhahan
Keywords
Related Articles
- EP ID EP334270
- DOI 10.7860/JCDR/2017/25036.9596
- Views 96
- Downloads 0
Sodium Valproate Induced Alopecia: A Case Series
Drug induced alopecia may range from a barely detectable shedding to an irreversible baldness. Alopecia associated with valproate is a dose-dependent and reversible side effect. We hereby report, three cases of alopecia...
Cardiovascular Response and Serum Interleukin-6 Level in Concentric Vs. Eccentric Exercise
Introduction: Cardiovascular Disease (CVD) is a leading cause of morbidity and mortality in India. Resistance exercise is strongly recommended for implementation in CVD prevention programs. Dynamic resistance exercise co...
Comparison of Cone Beam Computed Tomography and Multi Slice Computed Tomography Image Quality of Human Dried Mandible using 10 Anatomical Landmarks
Introduction: Cone Beam Computed Tomography (CBCT) has gained a broad acceptance in dentomaxillofacial imaging. Computed Tomography (CT) is another imaging modality for diagnosis and preoperative assessments of the head...
Rare Case of Symptomatic Ovarian Leiomyoma in Perimenopausal Woman
ABSTRACT Leiomyoma is a very rare benign tumour to be found in ovary. Here, we report a case of 40-year-old perimenopausal women with large left ovarian mass. The Computerised Tomography (CT) showed left ovarian solid ma...
Stereomicroscopic Dye Leakage Measurement of Six Different Root Canal Sealers
Introduction: Hermetic sealing of the root canal is the most desirable outcome of any root canal treatment, but almost always the filling of the root canal is defective, which is a multifactorial outcome. One such factor...