EFFECT OF SOME HERBAL DRUGS ON HAEMATOLOGICAL PROFILES OF RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
Excessive use of oestrogen or ethinyl oestradiol (EO, a semisynthetic 17b-oestradiol as highly potent oestrogen) can cause many detrimental effects, including cancer in humans as well as in animals. On the other hand, many herbal drugs are beneficial for the treatment of toxicity and cancer. Likewise, ProImmu and its plant-ingredients have been reported to possess immunomodulatory effect and restore the normal histoarchitecture of the damaged tissues. In the present study, the beneficial effects of ProImmu, and its two ingredients, viz., Tinospora cordifolia and Withania somnifera have been observed against EO altered haematological profiles in the female albino rats. The haematological study showed that EO (@ 250 μg/kg, orally, thrice a week) altered levels of haemoglobin (Hb), total leucocyte count (TLC) and differential leucocyte count (DLC- lymphocyte, monocyte, neutrophil and eosinophil) could be significantly normalized by ProImmu (@ 150 mg/kg, orally, daily for 8 weeks); however, the normalization of these parameters brought up by T. cordifolia (@ 250 mg/kg, orally, daily for 8 weeks) and W. somnifera (@ 250 mg/kg, orally, daily for 8 weeks) was found to be of lesser degree. ProImmu (@150 mg/kg, orally, daily for 12 weeks), T. cordifolia (@250 mg/kg, orally, daily for 12 weeks) and W. somnifera (@ 250 mg/kg, orally, daily for 12 weeks) also caused the normalcy of these parameters, but to less extent than observed on the 8 weeks.
Authors and Affiliations
S. Madhuri , Govind Pandey, Asha Khanna, A. B. Shrivastav, M. A. Quadri
Keywords
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