Effect of the combined administration of ethanol and acamprosate on rabbit EEG.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 1
Abstract
Central effect of ethyl alcohol and acamprosate is based on similar mechanisms. It is mainly connected with their effect on GABAergic, glutamatergic, serotonergic and opioid transmission. Thus, the question arises whether acamprosate administered together with alcohol increases acute central effects of ethanol. We have studied the effect of joint administration of acamprosate with ethanol in rabbits on EEG results from: frontal cortex, hippocampus and midbrain reticular formation. Acamprosate was applied into the stomach at a single dose of 400 mg kg(-1) or repeated doses of 200 mg kg(-1)/day (for 14 days). Ethanol at the dose of 0.8 g kg(-1) was administered iv 120 min after a single dose of acamprosate, or 4 h after the last dose of the drug. Ethanol caused an increase in the slow frequencies (0.5-4 Hz) in the recording, as well as a marked decrease in the fastest frequencies (13-30 and 30-45 Hz). Acamprosate administered jointly with ethanol increased the effect of ethanol on EEG recording; the amount of the fastest frequencies was decreased. When administered as repeated doses, it enhanced alcohol-related changes in EEG, both within slow and fast frequencies. Consumption of ethanol during acamprosate treatment may lead to intensification of central effects of ethanol.
Authors and Affiliations
Bogusława Pietrzak, Elżbieta Czarnecka
Keywords
Related Articles
- EP ID EP82261
- DOI -
- Views 127
- Downloads 0
Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C(60)(OH)(24) via suppression of oxidative stress.
Oxidative stress has an important role in the pathogenesis of doxorubicin (DOX)-induced nephrotoxicity. The aim of this study was to investigate the nephroprotective effects of fullerenol (FLR), an antioxidant agent, on...
Frequency of common MDR1 gene variants in a Polish population.
P-glycoprotein (P-gp) is a transmembrane transporter playing an important role in drug efflux. There is growing evidence that P-gp activity may be related to haplotypes of MDR1 gene. In the current study, the frequencies...
Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi.
Background: The effect of the agonism on γ-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally...
Non-epilepsy uses of antiepilepsy drugs.
Antiepileptic drugs (AEDs) affect various neurotransmitters (i.e. GABA, glutamate), receptors (i.e. GABAergic, glutamatergic), and ion channels (i.e. for sodium or calcium) which is responsible for their anticonvulsant a...
Pleiotropic effects of angiotensin-converting enzyme inhibitors in normotensive patients with coronary artery disease.
Angiotensin-converting enzyme inhibitors proved to be effective in the primary and secondary prevention of cardiovascular diseases. Clinical effectiveness of this group of agents may largely depend on their pleiotropic e...