EFFECT OF THE MONGOLIAN MEDICINE "GARLICLAXATIVE" IMPACT THERAPY ON ALCOHOLIC PERIPHERAL NERVE
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Objective: Using the Mongolian medicine "Garlic laxative," impact therapy on alcoholic peripheral neuropathy treatment mechanism for the Mongolian medicine application in the study of neurological diseases lay the foundation. Methods: Randomly selected 50 adult male rats as experimental animals and divided into some groups such as control group (Con group), model group (Model group), Methycobalgroup (Mecbl group), “Garlic change laxative” side group (Garlic group) and thecombinedmethycobal "Garlic laxative" group (Mecbl + Garlic group), 10 models in each group. Results: Electrophysiological test results showed that the conduction velocity of the sciatic nerve in rats was significantly slowed down after model establishment (P <0.05), and the nerve conduction velocity in model group was the slowest after the model was established. The nerve conduction velocity in Mecbl + Garlic group was the fastest Model group, Mecbl group and Garlic group (P <0.05), slightly higher than Con group, but no significant difference (P> 0.05). ELISA results showed that after model establishment, the expression of nerve growth factor (P <0.05). After the administration, the concentration of nerve growth factor in the model group was the lowest. Moreover, the nerve growth factor in Mecbl + Garlic group was the highest, significantly higher than that in Model group, Mecbl group and Garlic group (P <0.05) Mecbl + Garlic group compared with Con group, slightly higher but no significant difference (P> 0.05). Conclusions: The rat models of alcoholic axial neuropathy were established and treated for eight weeks respectively. The indexes of 5 rats were evaluated. The nerve conduction velocity was detected by the electrophysiological method and the enzyme-linked immune-sorbent assay Concentration of Nerve Growth Factor in Rats. Thus prove the Mongolian medicine "Garlic laxative" has a significant effect on the regulation of sciatic nerve conduction and the related factors of nerve factors in alcoholic peripheral neuropathy rats, which may have positive significance for the treatment, which deserves attention.
Authors and Affiliations
Dr. Tao Li
Keywords
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