Effect of Topical Cyclosporine in grading of Vernal keratoconjunctivitis.
Journal Title: BJKines-National Journal of Basic & Applied Science - Year 2017, Vol 9, Issue 1
Abstract
Background & Objective: To evaluate efficacy of topical aqueous solution of 0.05% cyclosporine in first time diagnosed vernal keratoconjunctivitis (VKC) including palpebral, bulbar and mixed form. Methods: 25 patients of VKC received CsA 0.05% aqueous ophthalmic solution in a dosage of one drop every 12 hours in both eyes for 6 months. Follow up visits (day 1, 2 weeks, 1 month, 2 months, 3 months and 6 months). Five symptoms were evaluated and six clinical signs were charted. Total objective score of 13 or more over atleast 3 variables was included (CART – scoring system). Results: Comparison of 1st Day with 2 weeks score showed no significant effect in the score value (t=0.90, df = 24, p<0.1). 1st Day with 3rd month score showed maximum effect in the score value (t = 35.76, df = 24, p<0.0001). 3rd month with 6th month score showed sustained effect of cyclosporine showing no major change in the score line (t test, t = 1.80, df = 24, p <0.05). Conclusion: Topical application of a 0.05% CsA aqueous solution has been shown to be effective in the treatment of patients with VKC. CsA could be an important alternative to steroid treatment.
Authors and Affiliations
Dr. Krupali Raol, Dr. Chintan Sarvaiya
Keywords
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