Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 6
Abstract
In the present study, we investigated plasma corticosterone levels of genetically modified mice lacking noradrenaline transporter (NET(-/-)), in response to the forced swim test (FST) and tail suspension test (TST). FST strongly increased the plasma corticosterone level in the first minute after the test (significantly only in NET(+/+) mice), while TST was without any significant effect in both genotypes studied. A single dose of tianeptine (20 mg/kg, ip) shortened immobility time in both tests in NET(-/-) mice, as well as NET(+/+) mice subjected to FST, but not TST. The lack of effect of tianeptine in control animals (NET(+/+)) subjected to TST is also reflected in unchanged levels of plasma corticosterone.
Authors and Affiliations
Joanna Solich, Paulina Pałach, Bogusława Budziszewska, Marta Dziedzicka-Wasylewska
Keywords
Related Articles
- EP ID EP123824
- DOI -
- Views 80
- Downloads 0
Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice.
Background: Cytisine (CYT), the most commonly used drug for smoking cessation in Poland, was experimentally found to induce convulsions. There is a lack of studies on the influence of CYT on the anticonvulsant activity o...
Neurochemical and behavioral effects of 8-OH-DPAT following exposure to restraint stress in rats.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-hydroxytryptamine 1A (serotonin; 5-HT(1A)) agonist was used to evaluate the role of somatodendritic and/or postsynaptic 5-HT(1A) receptors following expos...
CYP2D6 phenotyping with dextromethorphan.
Genetically determined individual differences in the ability to oxidize certain drugs have raised recently a considerable interest because of clinical importance of this problem. Determination of CYP2D6 oxidation phenoty...
Purvalanol A, inhibitor of cyclin-dependent kinases attenuates proliferation of cells in the dentate gyrus of the adult rat hippocampus.
Several recent findings indicate that intensity of neurogenesis in adult brain might be regulated by enzymes involved in the cell cycle. Therefore, in the present study, we investigated whether the inhibition of cyclin-d...
Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures.
The efficacy of lamotrigine and felbamate against maximal electroshock (MES)-induced seizures was assessed under conditions mimicking the pharmacoresistance associated with an increased excitatory neurotransmission. N-me...