Effect of Varicocelectomy on Restoration of Spermatogenesis in Patients with Non-obstructive Azoospermia
Journal Title: JOURNAL OF UROLOGICAL SURGERY - Year 2019, Vol 6, Issue 2
Abstract
Objective: The aim of this study was to investigate the effect of varicocelectomy on spermatogenesis in patients with non-obstructive azoospermia (NOA) and the presence of clinical factors for re-spermatogenesis. Materials and Methods: A total of 32 patients with clinically significant varicocele, who received the diagnosis of infertility, were included in this study. Microsurgical inguinal varicocelectomy and testicular biopsy were performed in all patients. After varicocelectomy, control spermiogram samples were collected from patients at 3rd, 6th and 12th months. The role of age, testicular volume, hormone parameters and pathological findings in predicting re-spermatogenesis were investigated. Results: The mean age of the patients who underwent surgery was 31.4±6.2 years. After varicocelectomy, sperm was detected in semen in 15.6% (5/32) of the patients. As a result of pathological evaluation, hypospermatogenesis, maturation arrest and germ cell aplasia were found in 34.4%, 31.2% and 34.4% of patients, respectively. The testicular volume was higher in patients with re-spermatogenesis (p=0,01). There was no statistically significant difference between responders and non-responders in terms of other investigated parameters. Conclusion: Varicocelectomy is an acceptable modality of treatment for patients with NOA with clinically significant varicocele. On the other hand, appropriate patient selection is crucial. In this study, testicular volume was found to be a predictive factor for recovery of spermatogenesis after varicocelectomy.
Authors and Affiliations
Oktay Özman, Sinharib Çitgez, Fatih Şimşekoğlu, Berin Selçuk, Sami Berk Özden, Hamdi Özkara
Keywords
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- EP ID EP581568
- DOI 10.4274/jus.galenos.2018.2333
- Views 114
- Downloads 0
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