Effect of Xylopia aethiopica, Fiscus mucuso and Anthocleista vogelli Extracts on Some Biochemical Parameters Following Ethanol-induced Toxicity
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 14
Abstract
The objective of the study was to comparatively verify the effects of aqueous extracts of three plants on some biochemical parameters following ethanol administration with a view to ascertaining the role of the extracts in ameliorating ethanol toxicity. A total of forty rats were divided into eight groups (n=5). Group A were control rats; Group B were administered with absolute ethanol; Group C were ethanol administered rats treated with Xylopia aethiopica; Groups D were ethanol administered rats treated with Fiscus mucuso, Group E were ethanol administered rats treated with Anthocleista vogelli; Group F were normal rats administered orally with Xylopia aethiopica; Group G were normal rats administered orally with Fiscus mucuso; Group H were normal rats administered orally with Anthocleista vogelli. At the end of the experimental period, the animals were sacrificed and serum was obtained for total protein, uric acid, creatinin, urea, aspartate aminotrasferase (AST) and alanine aminotransferase (ALT) analysis using respective research kits. The result showed that Xylopia aethiopica had protective effect on the kidney as compared with Fiscus mucuso and Anthocleista vogelli treated rats. Also, The AST and ALT was lowered with the beginning of Xylopia aethiopia treatment. The total protein, creatinin and urea were slightly (p>0.05) affected with ethanol, an effect which was normalized with the beginning of extract treatment. It can be concluded that Xylopia aethiopica had a better reno-protective and hepatoprotective effect than Anthocleista vogelli and Fiscus mucuso extract as evident in its ameliorative role on the biochemical profiles.
Authors and Affiliations
A. O. Ayoka, R. E Okonji, D. A. Ofusori, O. A. Komolafe, K. D. S. Bamitale, J. B. Fakunle
Keywords
Related Articles
- EP ID EP349270
- DOI 10.9734/BJMMR/2014/7779
- Views 68
- Downloads 0
Assessment of Anti-inflammatory and Anti-nociceptive Properties of Aqueous Seed Extract of Carica papaya in Albino Wistar Rats
This study was undertaken to assess analgesic and anti-inflammatory properties of seed extract of Carica papaya. Aqueous extracts of the plant at doses of 100, 200, and 300 mg/kg body weight were used for the study on fi...
Comparative Effects of Sevoflurane and Desflurane on Erythrocyte Deformability in Streptozotocin-induced Diabetic Rats
Aim: It is known that blood viscosity and erythrocyte aggregation are increased and erythrocyte deformability is decreased in diabetic patients. Blood rheology is known to be affected by numerous factor including anaesth...
Development of a Theoretical Model for the Appreciation of the Perception of Quality of Work Life and Occupational Stress, and Its Validation through Statistical Analyses
The present study describes the development of a theoretical model and a questionnaire measuring the perception of Quality of Worklife (QWL) and Occupational Stress (OS), as well as their validation through statistical a...
Salivary α-amylase Activity and s-IgA Levels Could be Taken as a Measure of Physiological Stress in Wheelchair-dependent Persons with Physical Disabilities and Without Disability Middle-aged Persons
Aims: The s-IgA/total protein ratio and α-amylase activity in saliva have been used as indexes of stress because they change according to the physiological stress. Using both indexes, this study aimed to compare the circ...
Correlation of Platelet Distribution Width [PDW], Mean Platelet Volume [MPV] and Red Cell Distribution Width [RDW] with Serum Blood Sugar Levels: A Case- control Study in the West Luck Now Population
Background: Diabetes itself is known to have long standing complications of both micro-vascular as well as macro vascular type. One of the life threatening complications that diabetes gives rise to is stroke and Ischemic...