Effect ofaddition of trimetazidine on LV function in patients with LV systolic dysfunction receiving optimal medical therapy in comparison with patients receiving only optimal medical therapy in a tertiary care centre
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 10, Issue 3
Abstract
Background: Left ventricular dysfunction (LVD) can lead to congestive cardiac failure.LVD was traditionally managed by antiplatelets, diuretics, antihypertensives and statins. However studies have shown that addition of Trimetazidine(TMZ) to standard treatment improve LV function and thus symptomatic improvement in patients. Many studies from western countries have shown beneficial effect of Trimetazidine in terms of LV function improvement.However not much data is available regarding the effect of Trimetazidine on LV function in Indian population. Hence this study was plannedin Indian population.Objectives: To find the effect ofaddition of Trimetazidine onLeft ventricular function, in patients with LV systolic dysfunction receiving optimal medical therapyin comparison with patients receiving only optimal medical therapyMaterialsand Methods: Studywas conducted in Department of Cardiology,KannurMedical College,Anjarakandy. Approval fromInstitutional HumanEthical Committee and Research Committeewas obtained.Thisis acomparativestudy in patients with LV systolic dysfunction receivingTrimetazidinealongwith optimal medical therapyand patients receiving only optimalmedical therapy.Study period was from November 2014 to August 2015.Results: In TMZ group, left ventricular systolic function improved significantly compared to optimal medical therapy group. In TMZ group LEVF showed an improvement of 42.56±6.59 vs 35.63±4.70 with a p value of <0.001.Conclusion: TMZ, a specific partial inhibitor of FFA oxidation, added to optimal medical therapy improved left ventricular function.Although highly suggestive, evaluation of effects of partial free fatty acid oxidation inhibition in patients with LVD requires further investigation through large scale, multicentre, randomised placebo controlled trials.Whether the observed beneficial effect of metabolic modulation in LVD, results in decreased morbidity and mortality, needs further evaluation as well.
Authors and Affiliations
Shabnam Narayanan, P N Krishna Kumar
Keywords
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