Effective analysis of Atorvastatin versus in Simvastatin patients with hyperlipidemia.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
We directly evaluate the safety and dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA)reductase inhibitor atorvastatin (X-tor) and simvastatin (Zocor) in hypercholesterolemic patients.Fifty hyperlipidemia patients between the ages of 20 and 75 years with baseline of low-density-lipoprotein(LDL) cholesterol (>160 mg/dl) and triglycerides (>400 mg/dl) received once-daily dosing withatorvastatin 10, 20 mg or simvastatin 10, 20 mg. The efficacy end points were mean percent change inplasma LDL cholesterol, total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C)concentrations from baseline to the end of treatment (week 8). Atorvastatin 10, 20 mg caused significantlygreater reductions in total cholesterol, LDL cholesterol and apolipoprotein B, respectively, than themilligram equivalent doses of simvastatin. On the other hand Atorvastatin 10 mg caused triglycerides andHDL cholesterol were not different between atorvastatin and the other reductase inhibitors except at the 20-mg dose when atorvastatin produced significant changes in triglycerides and HDL cholesterol thansimvastatin. No patient in either treatment group had clinically important elevations in creatinephosphokinase (CPK), alanine aminotransaminase (ALT), or aspartate aminotransaminase (AST). Noserious adverse events were considered associated with treatment. In summary, there is a need for moreeffective total cholesterol and LDL lowering agents to improve treatment aimed at reducing risk ofcoronary heart diseases (CHD). In this trial, atorvastatin was more effective than simvastatin. Atorvastatinshould constitute an important therapeutic option for patients with hyperlipidemia.
Authors and Affiliations
Palanisamy Pasupathi, Saravanan G, Rao Y. Y. , Farook J. , Bakthavathsalam C.
Keywords
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