Effectiveness of Glucosamine and Chondroitin Sulfate Combination in Patients with Primary Osteoarthritis
Journal Title: Applied Medical Informatics - Year 2010, Vol 27, Issue 4
Abstract
[i]Purpose[/i]: Studying the effectiveness of chondroprotective agents for patients with primary knee arthritis or primary generalized osteoarthritis, according to the American College of Rheumatology 2000 criteria. [i]Material and Methods[/i]: comparative study, the groups were constituted out of 25 patients in the study group and 15 patients in the control group. The patients were evaluated with the WOMAC test, Lequesne, cross-linked C-terminal (CTX) telopeptide of type I collagen on inclusion, at 6 and 12 months and through bilateral- knee radiography, using the Kellgren-Lawrence classification on inclusion and 12 months later. Patients from the study group received a chondroprotectiv agent orally for 12 months. [i]Results[/i]: WOMAC score was improved in the study group at 6 and 12 months -4.1 (CI -6.1 to -2.1) and -5.9 (CI -8 to -3.8) compared to the control group 1.5 (CI -0.7 to 3.7) and 2 (CI -0.2 to 4.2), with a statistical significance p=0.02. There has also been an amelioration of the Lequesne score in the study group at 6 and 12 months -3.8 (CI -6.3 to -1.3) and -6.2 (CI -9.1 to -3.3), and the control group 1.3 (CI -1.5 to 4.1) to 6 months and 1.9 (CI -0.8 to 4.6) to 12 months, with a statistical significance p=0.03. No adverse reactions were registered. [i]Conclusions[/i]: The chondroprotective agent was effective in improving the function of patients with osteoarthritis, the studied marker cannot be used to monitor the treatment effectiveness, and the radiological modifications in the knee are statistically insignificant after 12 months of monitoring.
Authors and Affiliations
Laszlo IRSAY, Monica BORDA, Andreea NITU, Viorela CIORTEA, Ioan ONAC, Rodica UNGUR
Keywords
Related Articles
- EP ID EP107933
- DOI -
- Views 74
- Downloads 0
Virtual reality for stroke rehabilitation: characteristics of protocols, pilot and feasibility studies
Introduction: Virtual reality (VR) for stroke rehabilitation is a therapeutic intervention expected to follow the randomized control trials (RCTs) requirements. This study aimed to identify the characteristics of protoco...
NUTRIBASE - Data Base for Nutritional Evaluation and Dietetic Treatment in Populational Metabolic Diseases
The nutritional evaluation and diet prescription are laborious and require much time. They need calculations of basic nutritional indices, to precisely diagnose and finally to indicate the proper nutritional recommendati...
An Entropy-Based Computer Model for the Measurement of Phonetic Similarity: Dyslalia Screening in Early School-Age Children
This paper presents a computer model for the assessment of the similarity between two sound patterns, to identify phoneme mispronunciations circumscribed by dyslalic disorders in early school-age children (6-10 year olds...
Serum Anti-Hbs-Ag in Stable Hemodialysis Patients and its Relationship with Various Demographic and Biochemical Data
[i]Introduction[/i]: To evaluate the relationship between various biochemical, nutritional and demographic factors with immune response to hepatitis B vaccine in maintenance hemodialysis (HD) patients. [i]Material and Me...
A Knowledge-Based Prototype to Support the Intelligent Diagnosis of High-Risk Pregnancy
High-risk pregnancy identification (HRP) involves data interpretation and analysis by experts of pregnancy characteristics, and similar prior experiences; this task can be complex depending on the characteristics of the...