Effectiveness of Injectable Artesunate Versus Quinine in The Treatment of Severe Malaria in Children Aged 0-59 Months in Kenge, DRC
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 18, Issue 3
Abstract
Malaria Threatens globally the lives of 3.3 trillion people living in 109 countries. This study compares the effectiveness avocation to of the drug artesunate versus quinine That of in the treatment of severe malaria Among the children of less than 59 months. For That reason, a survey and quantitative cross-sectional analysis has documentary Were Conducted one year based design to suit les explanatory correlation has entre les drugs and the rate of malaria treatment. A sample size of 380 children Was selected from the City of Kenge, half of Whom Were Treated with artesunate (190 children) and the other half with quinine (190 children). Results indicate indication at 5% significance level That 59% of patients Treated with artesunate drug Had a drop in temperature During the first day of treatment contre 49.5% Treated with drug quinine. The cure rate Was Observed 88. 9% for the artesunate group versus 83.7% for the quinine group. The death rate Was Established at 7.9% for the quinine group contre 1.1% for the artesunate group. Finally, a correlation Was Established entre les kind of treatment, parasitaemia at the start of the treatment, the adjuvant treatment, the Evolution of clinical signs During treatment, the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria. the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria. the final assessment, and the treatment effectiveness. Hence, the artesunate Was found to be more effective than quinine in Treating severe malaria.Malaria threatens 3.3 billion people in 109 countries in the world. This study aimed to compare the effectiveness of artesunate versus quinine in the treatment of severe malaria in children aged 0-59 months. We conducted a cross-quantitative investigation; correlational explanatory quote based on the literature review. A sample of 380 children was selected in the City of Kenge, of which 190 treated with artesunate and half treated with quinine. The results indicate a 5% significance level of 59% of patients treated with artesunate experienced a temperature drop on the first day against 49.5% treated with quinine. Moreover, the cure rate was 88.9% observed in the group of artesunate against 83.7% in the group of quinine. The death rate it was 7.9% in the group of quinine against 1.1% in the group of artesunate. Finally, interdependence were established between the established treatment parasitaemia at the beginning of treatment, adjuvant treatment, the evolution of clinical symptoms during treatment, the final evaluation and treatment efficacy. In conclusion, artesunate was more effective than quinine on the treatment of severe malaria or severe malaria.Malaria is a major public health problem that threatens 3.3 billion people in 109 countries around the world, especially in SubSaharan Africa, with high mortality, in the order of 1 death every 30 seconds in children under 5 years old. Its socio-economic impact is in the billions of dollars [1]. While the entire population seems to be at risk of infection, children under 5 years and pregnant women are the most affected [2]. In the Democratic Republic of Congo (DRC), malaria is a major public health problem. It is the leading cause of morbidity and mortality especially among children under five and pregnant women. This disease killed 467,000 people, including 200,000 children aged 0-59 months, according to figures released by the Ministry of Health in 2000 with an average of 500,000 deaths per year [3].
Authors and Affiliations
Prisca Nsimba Mayamba, Joel Kafumbi Katsiatsia, Cush Ngonzo Luwesi, Jean-Jacques Kisaka Ngimbi, Gertrude Lundu Yenamawu
Keywords
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- EP ID EP620603
- DOI 10.26717/BJSTR.2019.18.003155
- Views 141
- Downloads 0
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