Effectiveness of Mifipristone in the treatment of Uterine Leiomyoma
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 10
Abstract
Aim: To evaluate the efficacy of oral mifepristone in decreasing the severity of symptoms and in decreasing uterine and fibroid volume. Methods: This was a prospective study conducted in the department of Obstetrics and Gynaecology, Prathima Institute of Medical Sciences, Karimnagar, Telangana. Fifty symptomatic patients with fibroids received 25 mg of mifepristone daily for 3 months . Baseline data regarding Hb value, pictorial blood loss assessment chart (PBAC), visual analogue scale(VAS), Uterine volume and Fibroid volume were compared with those recorded at the end of 1st month, 3rd month and 3 months after stoppage of mifepristone. Results: Treatment with Mifepristone significantly reduced mean PBAC score by 95% after 1 month, 98% after 3 months and by 58% three months after completion of treatment compared to the pre-treatment value. Mean VAS score was reduced by 67% after 1 month, 72% after 3 months and by 47% three months after stoppage of drug to pre-treatment value. Mean uterine volume was reduced by 24% after 1 month, 44% after 3 months and by 35% in post treatment follow up patients compared to pre-treatment value. Mean baseline fibroid volume was reduced by 25% after 1 month, 54% after 3 months and by 40% in post treatment follow up patients. Though all these parameters slightly raised after stopping mifepristone, they are still significantly reduced compared to baseline values. Haemoglobin was raised by 2.12 gm/Dl from baseline at the end of 3rd month of therapy but slightly decreased compared to values of 3rd month treatment. Baseline endometrium was 7.4 mm which was increased to 8.24 mm after 3 months of treatment, it has come down to the baseline value which shows that endometrial thickness during treatment was transient. 88% of patients became amenorrhoeic after treatment but menstruation was resumed in 32.78% patients in post treatment follow up patients. There were minimal side effects during the course of study. Conclusion: Low dose oral Mifepristone 25 mg for 3 months significantly reduced Menorrhagia, backache, dysmenorrhoea and other associated symptoms , decreased uterine and fibroid volume and improved Haemoglobin levels with minimal side effects.
Authors and Affiliations
Dr. Alla Satyanarayana Reddy
Keywords
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