Effectiveness of Small-volume, Intralesional, Delayed-release Triamcinolone Injections in Cheilitis Granulomatosa: A Pilot Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Orofacial granulomatosis is an uncommon disease, which presents as recurrent or persistent swelling of the soft tissues of oral and maxillofacial region, predominantly lips - termed as Cheilitis Granulomatosa (granulomatous cheilitis). It may give rise to significant cosmetic and functional problems. Treatment with high-volume triamcinolone injections has been shown to be effective but requires local anesthesia (nerve block) and causes a dramatic temporary increase of lip swelling. A non-comparative open-label pilot study using small volume of high-concentrate extended release intralesional triamcinolone injections were performed in 7 patients with cheilitis granulomatosis in order to evaluate its effectiveness in reducing lip swelling and preventing recurrences. Material and Methods: Seven patients with granulomatous cheilitis were studied. Small-volume, intralesional, highconcentrate, extended release triamcinolone was injected on a weekly basis. A standard cycle consisted of 2 or 3 injection sessions over 2 or 3 weeks, depending on the clinical response. Results: After cycle completion, all patients remained without recurrences or with cosmetically acceptable slight lip enlargement for a mean time of 13.5 months (range, 8-19 months). No side effects were seen, except in one patient who developed hypopigmentation of the skin of the upper lip. Conclusion: Intralesional, high-concentrate, extendedrelease triamcinolone injections in small volume appears to be an effective treatment in reducing the enlargement of lips in patients with granulomatous cheilitis and at the same time do not require nerve block anesthesia or cause a temporary troublesome increase of swelling. A long disease-free period is generally obtained.
Authors and Affiliations
Rizwan Hamid, Altaf Chalkoo, Bashir Wani, Gazanfer Shah, Ubaid Ullah Gul Salmani
Keywords
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