Effects of Administering Soft Drinks on Some Biochemical Parameters and Histopathology of Liver in Wistar Rats
Journal Title: International Journal of Medical Science and Dental Research - Year 2018, Vol 1, Issue 1
Abstract
The ruling of the Lagos High Court at Igbosere, Nigeria on the 13th March, 2017 gave birth to this research work. The court ordered NAFDAC to enforce the Nigerian Bottling company (NBC) to write warnings on the potential dangers of taking soft drinks, especially with Vitamin C on their drinks. Twenty-five albino rats (weighing 194±9.5g) were randomly assigned to five groups (n=5). The soft drinks were labeled A, B, D, “A + Vitamin C” (400mg/20ml) and distilled water (control) were administered orally to groups 1, 2, 3, 4 and 5 respectively for 14 days. The administration was done in accordance with Pedro Montilla‟s method (400ml/70kg body weight).The rats were Sacrificed and subjected to biochemical and histological analysis. The levels of AST, ALT, TB and DB for soft drinks B, A, D and “A+ Vitamin C” were significantly higher (P<0.05) than the control. This is a strong marker for potential liver dysfunction. Similarly, A and “A+ vitamin C” significantly increased (P<0.05)bad cholesterol while weight and histological results of rats are normal. Moreover, the amount of soluble sugars found in D is more than double the level approved by the Standard Organization of Nigeria (SON).All the soft drinks are biological culprits as none is totally free of potential toxicity. This research supports the ruling of the High Court to include warnings of the potential dangers but consistently maintained that Vitamin C when added to soft drink A reduced its potential toxicity.
Authors and Affiliations
Kukoyi, Ayobami Jahdahunsi, Arowora, Kayode . Adebisi, Imo, Chinedu, Abongaby, Yohan
Keywords
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