EFFECTS OF ARTIFICIAL SWEETENER(ASPARTAME) ON THE WEIGHT OF IMMUNE ORGANS AND GRANULOCYTES CELLS IN RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 9
Abstract
This study aimed to determine the effect of aspartame on the white blood cells. Used for this study 24 adult male rats and 24 adult female rats, with age of 65-70 day, almost on an average live weight between (185-200) g. The experiment has concentrated on the daily dose, where the animals were randomly divided into two groups, each group contains 12animals females. the first, control groupdosed with 1ml physiologic solution daily, the second group gavage with concentrated aspartame (54 mg/kg/per day). The all groups had their daily dosages through the 75 day, and the experiment continued from October 2015- January 2016. After the dosage’s period has been completed, hematological samples have been taken from the rats to examine the count of neutrophils cells and isolation of spleen, thymus and lymph nodes to estimate the weight of it. The results showed there was significant decrease(P<0.05) in theneutrophil count, however no significant differences in monocyte and eosinophil count among groups, compared with the control group. Also showed that the weights of spleen, thymus and lymph nodes in aspartame treated animals were significantly decreased compared to control animals.
Authors and Affiliations
Ali Nayyef Umayra
Keywords
Related Articles
- EP ID EP672891
- DOI -
- Views 178
- Downloads 0
ISOLATION, IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF THE CARBAPENEMASE PRODUCING GRAM-NEGATIVE BACILLI
The emergence and spread of Carbapenemase-Producing Enterobacteriaceae (CPE) has been identified as a public health threat, especially since recent studies on CPE and Carbapenem-Non- Susceptible Enterobacteriaceae (CNSE)...
REVIEW OF LYCOPODIUM CLAVATUM WITH HOMEOPATHIC PERSPECTIVE AND MODERN PHARMACOLOGY
Homeopathy is the second most practiced system of medicine in the world next to the modern medicine. Chronic cases can be managed well without any adverse drug effects. Thus majority of people are seeking treatment with...
DENGUE FEVER WITH THROMBOCYTOPENIA: PEDIATRIC CASE REPORT
Dengue viral infection is a global health threat and it is the most rapidly spreading mosquito-borne viral disease in the world. A case of 9-year-old boy patient medically free presented to the emergency department with...
RETURN TO NATURE FOR EFFICACIOUS AND SAFER MEDICINAL PROSPECTS: A REVIEW
Traditional medicine also known as indigenous or folk medicine comprises medical knowledge systems that developed over generations within various societies before the era of modern medicine. We have gone through literatu...
COMPARATIVE STUDY OF VERTICAL MARGINAL FIT ON IMPLANT ABUTMENT USING METAL CERAMIC CROWNS, FULL CONTOUR ZIRCONIA CROWNS (CAD/CAM) AND VENEERED ZIRCONIA CROWNS (CAD/CAM) (AN IN VITRO STUDY)
Background: Marginal fitness is an important factor in success and longevity of implant – retained restoration. Poor fitness and too large discrepancy lead to seepage of debris, cement dissolution and microbial colonizat...